A: Brain regions in the PET study where insulin-stimulated GU was measured in carriers and noncarriers of the p.P50T/AKT2 variant. A: Brain regions in the PET study where insulin-stimulated GU was measured in carriers and noncarriers of the p.P50T/AKT2 variant. B: Significant differences (P value) in GU in the specific regions of the brain between noncarriers (blue bars, N = 25) and carriers (red bars, N = 20) of the p.P50T/AKT2 variant. Data are mean ± SD. Aino Latva-Rasku et al. Diabetes 2018;67:334-342 ©2018 by American Diabetes Association