Irene Rubio, Ph. D. , Reidun Kuhlmann, Inge Agerholm, Ph. D

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Presentation transcript:

Limited implantation success of direct-cleaved human zygotes: a time-lapse study Irene Rubio, Ph.D., Reidun Kuhlmann, Inge Agerholm, Ph.D., John Kirk, M.D., Javier Herrero, Ph.D., María-José Escribá, Ph.D., José Bellver, Ph.D., Marcos Meseguer, Ph.D. Fertility and Sterility Volume 98, Issue 6, Pages 1458-1463 (December 2012) DOI: 10.1016/j.fertnstert.2012.07.1135 Copyright © 2012 American Society for Reproductive Medicine Terms and Conditions

Figure 1 (A) Incidence rate of direct cleavage (≤5 hours) from two to three cells (DC2–3) for all embryos (n = 5,225). (B) Incidence rate of DC2–3 for transferred embryos (n = 1,659). Fertility and Sterility 2012 98, 1458-1463DOI: (10.1016/j.fertnstert.2012.07.1135) Copyright © 2012 American Society for Reproductive Medicine Terms and Conditions

Figure 2 Implantation of (A) direct cleavage two to three cells (DC2–3), 109 (7%) of transferred embryos, and (B) non-DC2–3, 1,550 (93%) of transferred embryos. The classifications are as follows: hCG neg = none of the transferred embryos resulted in a biochemical pregnancy; biochemical abortion = the treatment resulted in a biochemical abortion; clinical abortion = embryo(s) implanted but the treatment resulted in a clinical abortion; partial implantation = some of the transferred embryos implanted, thus the fate (implanted or not) of the specific embryo is unknown; known implantation = all transferred embryos in the treatment implanted. Fertility and Sterility 2012 98, 1458-1463DOI: (10.1016/j.fertnstert.2012.07.1135) Copyright © 2012 American Society for Reproductive Medicine Terms and Conditions