A, SSA/P is seen in the right colon (outlined by arrows) at colonoscopy. A, SSA/P is seen in the right colon (outlined by arrows) at colonoscopy. Note.

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A, SSA/P is seen in the right colon (outlined by arrows) at colonoscopy. A, SSA/P is seen in the right colon (outlined by arrows) at colonoscopy. Note the typical flat appearance of the lesion and common overlying mucus that can obscure its detection. B, Histopathology of a SSA/P shows the characteristic serrated or “sawtooth” appearance of the colonic crypts that are wide and lateral spreading at the base (arrow) of the polyp. C, SSA/P (down arrow) is seen contiguous with a colonic adenocarcinoma (up arrow). The cancer is poorly differentiated with an area of signet ring cells and was found to have MSI and a BRAF mutation. Shahrooz Rashtak et al. Cancer Prev Res 2017;10:270-278 ©2017 by American Association for Cancer Research

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