Keith A. Hansen, M. D. , Yueyi Zhang, M. D. , Robert Colver, M. D

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The dopamine receptor D2 genotype is associated with hyperprolactinemia Keith A. Hansen, M.D., Yueyi Zhang, M.D., Robert Colver, M.D., Sandra P.T. Tho, M.D., Leo Plouffe, M.D., Paul G. McDonough, M.D. Fertility and Sterility Volume 84, Issue 3, Pages 711-718 (September 2005) DOI: 10.1016/j.fertnstert.2005.03.040 Copyright © 2005 American Society for Reproductive Medicine Terms and Conditions

FIGURE 1 SSCP of the 251-bp fragment of exon 7 DRD2 demonstrated changing mobility in different controls and hyperprolactinemic patients. Subsequent sequencing of this fragment revealed polymorphism 1 at nucleotide 3420 and polymorphism 2 at nucleotide 3438 at the heterozygous (HTZ) or homozygous (HMZ) state or compound HTZ state for both polymorphisms. Hansen. Dopamine receptor D2 and hyperprolactinemia. Fertil Steril 2005. Fertility and Sterility 2005 84, 711-718DOI: (10.1016/j.fertnstert.2005.03.040) Copyright © 2005 American Society for Reproductive Medicine Terms and Conditions

FIGURE 2 Partial sequence of the antisense strand of the 251-bp fragment of exon 7 in a control, a homozygote for polymorphism 1 at nucleotide 3420, a homozygote for polymorphism 2 at nucleotide 3438, and a compound heterozygote for both polymorphism 1 and polymorphism 2. The G → A substitution for the antisense strand (corresponding C → T substitution for the sense strand) at nucleotides 3420 and 3438 does not change the amino acids histidine at position 313 and proline at position 319, respectively. Hansen. Dopamine receptor D2 and hyperprolactinemia. Fertil Steril 2005. Fertility and Sterility 2005 84, 711-718DOI: (10.1016/j.fertnstert.2005.03.040) Copyright © 2005 American Society for Reproductive Medicine Terms and Conditions

FIGURE 3 NcoI digestion of the 251-bp fragment of exon 7 of the DRD2 followed by electrophoresis in 8% polyacrylamide gel for wild-type exon 7 (lanes 1 and 8), individuals homozygous for polymorphism 1 (lanes 2, 3, and 4), and individuals heterozygous for polymorphism 1 (lanes 5, 6, and 7). Hansen. Dopamine receptor D2 and hyperprolactinemia. Fertil Steril 2005. Fertility and Sterility 2005 84, 711-718DOI: (10.1016/j.fertnstert.2005.03.040) Copyright © 2005 American Society for Reproductive Medicine Terms and Conditions