Oral administration of a dominant T-cell determinant peptide inhibits allergen-specific TH1 and TH2 cell responses in Cry j 2–primed mice Kazuki Hirahara,

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Presentation transcript:

Oral administration of a dominant T-cell determinant peptide inhibits allergen-specific TH1 and TH2 cell responses in Cry j 2–primed mice Kazuki Hirahara, MSa, Saburo Saito, MDb, Nobufusa Serizawa, PhDa, Reiko Sasaki, MDc, Masahiro Sakaguchi, PhDc, Sakae Inouye, MDc, Yoshifumi Taniguchi, MEd, Shuichi Kaminogawa, PhDe, Akio Shiraishi, PhDa Journal of Allergy and Clinical Immunology Volume 102, Issue 6, Pages 961-967 (December 1998) DOI: 10.1016/S0091-6749(98)70334-3 Copyright © 1998 Mosby, Inc. Terms and Conditions

Fig. 1 Proliferative responses of nasally-associated lymph node cells against Cry j 1, Cry j 2, and T-cell determinant peptides of Cry j 2. Results are indicated as mean ± SD of cpm. I.n., Intranasal. Journal of Allergy and Clinical Immunology 1998 102, 961-967DOI: (10.1016/S0091-6749(98)70334-3) Copyright © 1998 Mosby, Inc. Terms and Conditions

Fig. 2 Proliferative responses of LNCs from mice fed with p246-259 (A) or p70-83 (B) before being primed intranasally (I.n.) with Cry j 1 and Cry j 2. Results are indicated as mean ± SD of cpm. *P < .01 versus control group of mice. Journal of Allergy and Clinical Immunology 1998 102, 961-967DOI: (10.1016/S0091-6749(98)70334-3) Copyright © 1998 Mosby, Inc. Terms and Conditions

Fig. 3 Inhibited anti-Cry j 2 IgE (A) and IgG (B) antibody responses in mice fed with p246-259 before being primed intranasally (I.n.) with Cry j 2. Data are presented as mean ± SD. *P < .01 versus control group of mice. Journal of Allergy and Clinical Immunology 1998 102, 961-967DOI: (10.1016/S0091-6749(98)70334-3) Copyright © 1998 Mosby, Inc. Terms and Conditions

Fig. 4 Inhibited serum anti-Cry j 2 IgE antibody response in mice fed with p246-259 before being primed intraperitoneally (I.p.) with Cry j 2 and alum. Data are presented as mean ± SD. *P < .01 versus control group of mice. Journal of Allergy and Clinical Immunology 1998 102, 961-967DOI: (10.1016/S0091-6749(98)70334-3) Copyright © 1998 Mosby, Inc. Terms and Conditions

Fig. 5 Inhibited proliferative response of LNCs from mice fed with p246-259 after being primed intranasally (I.n.) with Cry j 2. Results are indicated as mean ± SD of cpm. *P < .01 versus control group of mice. Journal of Allergy and Clinical Immunology 1998 102, 961-967DOI: (10.1016/S0091-6749(98)70334-3) Copyright © 1998 Mosby, Inc. Terms and Conditions