Increased food diversity in the first year of life is inversely associated with allergic diseases Caroline Roduit, MD, MPH, Remo Frei, PhD, Martin Depner,

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Presentation transcript:

Increased food diversity in the first year of life is inversely associated with allergic diseases Caroline Roduit, MD, MPH, Remo Frei, PhD, Martin Depner, PhD, Bianca Schaub, MD, Georg Loss, PhD, Jon Genuneit, MD, Petra Pfefferle, PhD, Anne Hyvärinen, PhD, Anne M. Karvonen, PhD, Josef Riedler, MD, Jean-Charles Dalphin, MD, PhD, Juha Pekkanen, MD, Erika von Mutius, MD, MSc, Charlotte Braun-Fahrländer, MD, Roger Lauener, MD Journal of Allergy and Clinical Immunology Volume 133, Issue 4, Pages 1056-1064.e7 (April 2014) DOI: 10.1016/j.jaci.2013.12.1044 Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Association between increasing diversity of food introduced within the first year of life and asthma. A, Diversity score with major food for the entire study population. B, Diversity score with major food restricted to children without food avoidance within the first year of life because of allergies. C, Diversity score with all different food items for the entire study population. The solid line represents the predicted value of asthma as a function of the score, and dashed lines represent the CI. The y-axis is the linear logit of asthma, and the values are centered on 0 (50/50 odds) and extended to both positive and negative values. All models are adjusted for farmer, center, duration of breast-feeding, parents with allergy, maternal education, sex, and siblings. Journal of Allergy and Clinical Immunology 2014 133, 1056-1064.e7DOI: (10.1016/j.jaci.2013.12.1044) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Association between increasing diversity of food introduced within the first year of life and food allergy. A, Diversity score with major food for the entire study population. B, Diversity score with major food restricted to children without food avoidance within the first year of life because of allergies. C, Diversity score with all different food items for the entire study population. The solid line represents the predicted value of asthma as a function of the score, and dashed lines represent the CI. The y-axis is the linear logit of food allergy, and the values are centered on 0 (50/50 odds) and extended to both positive and negative values. All models are adjusted for farmer, center, duration of breast-feeding, parents with allergy, maternal education, sex, and siblings. Journal of Allergy and Clinical Immunology 2014 133, 1056-1064.e7DOI: (10.1016/j.jaci.2013.12.1044) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Association between increasing diversity of food introduced within the first 6 months of age and asthma. A, Diversity score with major food introduced within the first 6 months of life for the entire study population. B, Diversity score with all food items introduced within the first 6 months of life for the entire study population. The solid line represents the predicted value of asthma as a function of the score, and dashed lines represent the CI. The y-axis is the linear logit of asthma, and the values are centered on 0 (50/50 odds) and extended to both positive and negative values. All models are adjusted for farmer, center, duration of breast-feeding, parents with allergy, maternal education, sex, and siblings. Journal of Allergy and Clinical Immunology 2014 133, 1056-1064.e7DOI: (10.1016/j.jaci.2013.12.1044) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions