Transcriptomic changes in strains PAK and PAKpmrB6 in response to polymyxin B (PMB). Transcriptomic changes in strains PAK and PAKpmrB6 in response to.

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Transcriptomic changes in strains PAK and PAKpmrB6 in response to polymyxin B (PMB). Transcriptomic changes in strains PAK and PAKpmrB6 in response to polymyxin B (PMB). (A) PCA score plots of the first two components indicate transcriptomic changes in strains PAK and PAKpmrB6 with the treatment of 4 mg/liter PMB at 1 h (i) and 4 h (ii). Each data set represents three biological replicates of the two strains with and without PMB treatment. The values for untreated PAK (blue), PMB-treated PAK (cyan), untreated PAKpmrB6 (red), and PMB-treated PAKpmrB6 (green) are shown. (B) Venn diagrams show the numbers of upregulated genes (i) and downregulated genes (ii) in response to 4 mg/liter PMB in strains PAK and PAKpmrB6 (fold change > 2, FDR < 0.05). Mei-Ling Han et al. mSystems 2019; doi:10.1128/mSystems.00149-18