Volume 57, Issue 4, Pages (April 2000)

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Presentation transcript:

Volume 57, Issue 4, Pages 1736-1742 (April 2000) Increased protein loss during peritonitis associated with peritoneal dialysis is neutrophil dependent Qiong Luo, Alfred K. Cheung, Craig D. Kamerath, Larry G. Reimer, John K. Leypoldt, Ph.D. Kidney International Volume 57, Issue 4, Pages 1736-1742 (April 2000) DOI: 10.1046/j.1523-1755.2000.00019.x Copyright © 2000 International Society of Nephrology Terms and Conditions

Figure 1 Leukocyte counts (white blood cells; WBCs) in peritoneal dialysate as a function of dwell time during series 1 experiments (pretreatment with mustine). Results are shown after an intravenous injection of mustine using dialysate containing E. coli (□; N = 6), after an intravenous injection of saline using dialysate containing E. coli (○; N = 6), after an intravenous injection of mustine using a dialysate without bacteria (▪; N = 6), and after an intravenous injection of saline using a dialysate without bacteria (▪; N = 6). Error bars denote ± SEM, and double asterisks denote significant differences (P < 0.01) in WBCs at the specified sampling times. Kidney International 2000 57, 1736-1742DOI: (10.1046/j.1523-1755.2000.00019.x) Copyright © 2000 International Society of Nephrology Terms and Conditions

Figure 2 Dialysate to plasma concentration ratios (D/P) for total protein as a function of dwell time during series 1 experiments (pretreatment with mustine). Symbols are: (□) after an intravenous injection of mustine using dialysate containing E. coli (N = 6); (○) after an intravenous injection of saline using dialysate containing E. coli (N = 6); (▪) after an intravenous injection of mustine using a dialysate without bacteria (N = 6); (•) after an intravenous injection of saline using a dialysate without bacteria (N = 6). Error bars denote ± SEM, and double asterisks denote significant differences (P < 0.01) in D/P values at the specified sampling times. Kidney International 2000 57, 1736-1742DOI: (10.1046/j.1523-1755.2000.00019.x) Copyright © 2000 International Society of Nephrology Terms and Conditions

Figure 3 Dialysate to plasma concentration ratios (D/P) for creatinine as a function of dwell time during series 1 experiments (pretreatment with mustine). Symbols are: (□) after an intravenous injection of mustine using dialysate containing E. coli (N = 6); (○) after an intravenous injection of saline using dialysate containing E. coli (N = 6); (▪) after an intravenous injection of mustine using a dialysate without bacteria (N = 6); and (•) after an intravenous injection of saline using a dialysate without bacteria (N = 6). Error bars denote ± SEM. Kidney International 2000 57, 1736-1742DOI: (10.1046/j.1523-1755.2000.00019.x) Copyright © 2000 International Society of Nephrology Terms and Conditions

Figure 4 Leukocyte counts (WBCs) in peritoneal dialysate as a function of dwell time during series 2 experiments (pretreatment with mAb 60.3). Results are shown after an intravenous injection of mAb 60.3 using dialysate containing E. coli (□; N = 5), after an intravenous injection of saline using dialysate containing E. coli (○; N = 5), and after an intravenous injection of mAb 60.3 using a dialysate without bacteria (▪; N = 2). Error bars denote ± SEM, and single and double asterisks denote significant differences (P < 0.05 and P < 0.01, respectively) in WBCs at the specified sampling times. Kidney International 2000 57, 1736-1742DOI: (10.1046/j.1523-1755.2000.00019.x) Copyright © 2000 International Society of Nephrology Terms and Conditions

Figure 5 Dialysate to plasma concentration ratios (D/P) for total protein as a function of dwell time during series 2 experiments (pretreatment with mAb 60.3). Symbols are: (□) after an intravenous injection of mAb 60.3 using dialysate containing E. coli (N = 5); (○) after an intravenous injection of saline using dialysate containing E. coli (N = 5); (▪) after an intravenous injection of mAb 60.3 using a dialysate without bacteria (N = 2). Error bars denote ± SEM, and single and double asterisks denote significant differences (P < 0.05 and P < 0.01, respectively) in D/P for total protein at the specified sampling times. Kidney International 2000 57, 1736-1742DOI: (10.1046/j.1523-1755.2000.00019.x) Copyright © 2000 International Society of Nephrology Terms and Conditions