IL-9 and c-Kit+ mast cells in allergic rhinitis during seasonal allergen exposure: Effect of immunotherapy Kayhan T. Nouri-Aria, PhD, FRCPath, Charles.

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IL-9 and c-Kit+ mast cells in allergic rhinitis during seasonal allergen exposure: Effect of immunotherapy Kayhan T. Nouri-Aria, PhD, FRCPath, Charles Pilette, MD, PhD, Mikila R. Jacobson, PhD, Hiroshi Watanabe, MD, Stephen R. Durham, MD, FRCP Journal of Allergy and Clinical Immunology Volume 116, Issue 1, Pages 73-79 (July 2005) DOI: 10.1016/j.jaci.2005.03.011 Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 1 Effects of natural allergen exposure and allergen immunotherapy on IL-9 protein (A), IL-9 mRNA (B), and c-Kit (C) expression in the nasal mucosa. Data shown are for out-of-season (pre) and peak-season (post) nasal biopsy specimens in immunotherapy- and placebo-treated patients and nonatopic control subjects (peak only). Horizontal bars represent median values. Journal of Allergy and Clinical Immunology 2005 116, 73-79DOI: (10.1016/j.jaci.2005.03.011) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 2 Expression of IL-9 protein (immunohistochemistry [IMH], 200× magnification; a, IL-9 mRNA (in situ hybridization [ISH], 200× magnification; b, c-Kit+ mast cells (IMH, 200× magnification; c, and colocalization of IL-9 mRNA to CD3+ T lymphocytes (IMH/ISH, 400× magnification; d, and colocalization of IL-9 protein to CD3+ T lymphocytes (double immunofluorescence, 400× magnification; e, and IL-9 protein to MBP+ eosinophils (double immunofluorescence, 400× magnification; f, Arrows show IL-9–expressing cells. Journal of Allergy and Clinical Immunology 2005 116, 73-79DOI: (10.1016/j.jaci.2005.03.011) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 3 The contributions to IL-9 protein expression by T cells (CD3), eosinophils (major basic protein [MBP]), neutrophils (Elastase), and mast cells (Tryptase) are shown (A), and the proportions of T cells, eosinophils, neutrophils, and mast cells expressing IL-9 protein are shown (B). Contributions to IL-9 mRNA expression and proportions of IL-9 mRNA–expressing leukocytes are also shown (C and D, respectively). Journal of Allergy and Clinical Immunology 2005 116, 73-79DOI: (10.1016/j.jaci.2005.03.011) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions