Fig. 5 EGLN2-mediated HIF1A down-regulation promotes ferroptosis.

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Fig. 5 EGLN2-mediated HIF1A down-regulation promotes ferroptosis. EGLN2-mediated HIF1A down-regulation promotes ferroptosis. (A) Western blot analysis of the indicated proteins in control and EGLN2 knockdown (EGLN2KD) HT1080 and Calu-1 cells upon treatment with RSL3 (0.5 μM) for 12 hours. (B) Western blot analysis of the indicated protein expression in HT1080 and Calu-1 cells after treatment with RSL3 (0.5 μM) in the absence or presence of adaptaquin (4 μM) for 12 hours. (C and D) Analysis of MDA level (C) and cell death (D) in the indicated HT1080 cells subsequent to treatment with RSL3 (0.5 μM) in the absence or presence of chetomin (0.25 μM) and KC7F2 (25 μM) for 12 hours (n = 3, *P < 0.05). (E) Western blot analysis of the indicated proteins in control and HIF1A knockdown (HIF1AKD) HT1080 and Calu-1 cells following treatment with hypoxia (1% O2) for 24 hours. (F to I) Analysis of MDA level (F), cell death (G), lipid droplet (H), and gene mRNA (I) in the indicated hypoxia (1% O2, 24 hours)–pretreated HT1080 and Calu-1 cells after being cultured with RSL3 (0.5 μM) and FIN56 (5 μM) for 12 hours (n = 3, *P < 0.05). Minghua Yang et al. Sci Adv 2019;5:eaaw2238 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).