Guillermo A. Orsi, Monica Naughtin, Geneviève Almouzni  Cell Stem Cell 

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Presentation transcript:

The Epigenome and Cancer Stem Cell Fate: Connected by a Linker Histone Variant  Guillermo A. Orsi, Monica Naughtin, Geneviève Almouzni  Cell Stem Cell  Volume 19, Issue 5, Pages 567-568 (November 2016) DOI: 10.1016/j.stem.2016.10.010 Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 1 H1.0 Hetergeneity in Tumors Determines Cell Fate Decisions Following genetic changes that allow tumorigenic growth, cell populations emerge with cancer stem cells (SSEA1+), characterized by low H1.0 levels, and differentiated tumor cells (SSEA1−), with high H1.0 levels. The H1.0 gene itself is regulated by methylation of a CpG shore region within the H1.0 gene body and potential additional epigenetic switches. H1.0 silences self-renewal genes and may impact AT-rich heterochromatin, rDNA, and other repeat regions. Cell Stem Cell 2016 19, 567-568DOI: (10.1016/j.stem.2016.10.010) Copyright © 2016 Elsevier Inc. Terms and Conditions

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