Guillermo A. Orsi, Monica Naughtin, Geneviève Almouzni  Cell Stem Cell 

Slides:



Advertisements
Similar presentations
Distribution of Human Embryonic Stem Cell Lines: Who, When, and Where Jennifer B. McCormick, Jason Owen-Smith, Christopher Thomas Scott Cell Stem Cell.
Advertisements

Evolution of the Cancer Stem Cell Model Antonija Kreso, John E. Dick Cell Stem Cell Volume 14, Issue 3, Pages (March 2014) DOI: /j.stem
Identification and characterization of leukemia stem cells in murine MLL-AF9 acute myeloid leukemia Tim C.P. Somervaille, Michael L. Cleary Cancer Cell.
Module Map of Stem Cell Genes Guides Creation of Epithelial Cancer Stem Cells David J. Wong, Helen Liu, Todd W. Ridky, David Cassarino, Eran Segal, Howard.
IPSC Crowdsourcing: A Model for Obtaining Large Panels of Stem Cell Lines for Screening Mahendra Rao Cell Stem Cell Volume 13, Issue 4, Pages (October.
Fate Restriction and Multipotency in Retinal Stem Cells Lázaro Centanin, Burkhard Hoeckendorf, Joachim Wittbrodt Cell Stem Cell Volume 9, Issue 6, Pages.
Myc Represses Primitive Endoderm Differentiation in Pluripotent Stem Cells Keriayn N. Smith, Amar M. Singh, Stephen Dalton Cell Stem Cell Volume 7, Issue.
Shaping Genetic Alterations in Human Cancer: The p53 Mutation Paradigm Thierry Soussi, Klas G. Wiman Cancer Cell Volume 12, Issue 4, Pages (October.
Normal and Leukemic Stem Cell Niches: Insights and Therapeutic Opportunities Koen Schepers, Timothy B. Campbell, Emmanuelle Passegué Cell Stem Cell Volume.
Quantitative Single-Cell Approaches to Stem Cell Research Martin Etzrodt, Max Endele, Timm Schroeder Cell Stem Cell Volume 15, Issue 5, Pages (November.
Chemotherapy and Cancer Stem Cells
Illuminating the Properties of Prostate Luminal Progenitors
Cutaneous Cancer Stem Cells: β-Catenin Strikes Again
Cancer: Inappropriate Expression of Stem Cell Programs?
Human Naive Embryonic Stem Cells: How Full Is the Glass?
Volume 1, Issue 5, Pages (November 2007)
The Tailless Root of Glioma: Cancer Stem Cells
IL-22 Gets to the Stem of Colorectal Cancer
Martin Wahlestedt, David Bryder  Cell Stem Cell 
Linking miRNA Regulation to BCR-ABL Expression: The Next Dimension
Targeting Epigenetics to Speed Up Repair
Volume 1, Issue 1, Pages (June 2007)
Laetitia Seguin, Sara M. Weis, David A. Cheresh  Cell Stem Cell 
Cell Cycle Rules Pluripotency
Why Myc? An Unexpected Ingredient in the Stem Cell Cocktail
Improving Stem Cell Therapeutics with Mechanobiology
Volume 9, Issue 2, Pages (August 2011)
Epigenomics of Retinal Development in Mice and Humans
MSCs, Macrophages, and Cancer: A Dangerous Ménage-à-Trois
Mapping Human Epigenomes
Natalia J. Martinez, Richard I. Gregory  Cell Stem Cell 
Asif Rashid, Jean Pierre J. Issa  Gastroenterology 
Regulating Cancer Stem Cells the miR Way
Haunting the HOXA Locus: Two Faces of lncRNA Regulation
Wing Y. Chang, William L. Stanford  Cell Stem Cell 
Doria Filipponi, Julius Muller, Alexander Emelyanov, Dmitry V. Bulavin 
Stem Cell Therapies in Clinical Trials: Progress and Challenges
Why Myc? An Unexpected Ingredient in the Stem Cell Cocktail
Cutaneous Cancer Stem Cells: β-Catenin Strikes Again
TRRAP and the Maintenance of Stemness in Gliomas
MicroRNA Regulation of Stem Cell Fate
CHD7 in Charge of Neurogenesis
Learning the ABCs of Melanoma-Initiating Cells
MicroRNAs and Parallel Stem Cell Lives
The p27Kip1 tumor suppressor gene: Still a suspect or proven guilty?
Not So Lonely at the Top for Cancer Stem Cells
Location, Location, Location: The Cancer Stem Cell Niche
Glimpses of the Epigenetic Landscape
Enhanc(er)ing Skin Stem Cells
Mohammad Abdul-Ghani, Lynn A. Megeney  Cell Stem Cell 
Meddling with METTLs in Normal and Leukemia Stem Cells
Powering Reprogramming with Vitamin C
Regulating Autologous Adult Stem Cells: The FDA Steps Up
Timothy R. Donahue, David W. Dawson  Cell Stem Cell 
Charting a Map through the Cellular Reprogramming Landscape
Long Noncoding RNAs in Cell-Fate Programming and Reprogramming
To Infinium, and Beyond! Cancer Cell
Regulating Autologous Adult Stem Cells: The FDA Steps Up
The Tailless Root of Glioma: Cancer Stem Cells
Aging Stem Cells: Transcriptome Meets Epigenome Meets Methylome
Learning the ABCs of Melanoma-Initiating Cells
Tracy-Ann Read, Robert J. Wechsler-Reya  Cancer Cell 
Hariharan Easwaran, Hsing-Chen Tsai, Stephen B. Baylin  Molecular Cell 
Using Notches to Track Mammary Epithelial Cell Homeostasis
Epigenome Sequencing Comes of Age
Volume 142, Issue 7, Pages (June 2012)
Ye-Guang Chen, Zhongwei Li, Xiao-Fan Wang  Cell Stem Cell 
Of Mice and Man: Differential DNMT Dependence in Mammalian ESCs
Knocking the Wnt out of the Sails of Leukemia Stem Cell Development
Kevin Huang, Guoping Fan  Cell Stem Cell 
Presentation transcript:

The Epigenome and Cancer Stem Cell Fate: Connected by a Linker Histone Variant  Guillermo A. Orsi, Monica Naughtin, Geneviève Almouzni  Cell Stem Cell  Volume 19, Issue 5, Pages 567-568 (November 2016) DOI: 10.1016/j.stem.2016.10.010 Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 1 H1.0 Hetergeneity in Tumors Determines Cell Fate Decisions Following genetic changes that allow tumorigenic growth, cell populations emerge with cancer stem cells (SSEA1+), characterized by low H1.0 levels, and differentiated tumor cells (SSEA1−), with high H1.0 levels. The H1.0 gene itself is regulated by methylation of a CpG shore region within the H1.0 gene body and potential additional epigenetic switches. H1.0 silences self-renewal genes and may impact AT-rich heterochromatin, rDNA, and other repeat regions. Cell Stem Cell 2016 19, 567-568DOI: (10.1016/j.stem.2016.10.010) Copyright © 2016 Elsevier Inc. Terms and Conditions

Feedback: Privacy Policy Feedback
Do Not Sell My Personal Information
About project: SlidePlayer Terms of Service

© 2024 SlidePlayer.com. Inc. All rights reserved.