Peanut protein in household dust is related to household peanut consumption and is biologically active Helen A. Brough, MRCPCH, MSc, Alexandra F. Santos,

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Presentation transcript:

Peanut protein in household dust is related to household peanut consumption and is biologically active Helen A. Brough, MRCPCH, MSc, Alexandra F. Santos, MD, MSc, Kerry Makinson, MSc, Martin Penagos, MD, MSc, Alick C. Stephens, PhD, Abdel Douiri, PhD, Adam T. Fox, MD, MSc, George Du Toit, FRCPCH, Victor Turcanu, PhD, Gideon Lack, MD, FRCPCH Journal of Allergy and Clinical Immunology Volume 132, Issue 3, Pages 630-638 (September 2013) DOI: 10.1016/j.jaci.2013.02.034 Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Correlation between combined parental peanut consumption (grams per week) over 6 months and peanut protein levels in the maternal bed (A; n = 41; rs = 0.698; 95% CI, 0.460-0.811; P < .001) and paternal bed (B; n = 37; rs = 0.672; 95% CI, 0.475-0.829; P < .001). Axes are displayed in log scale. Journal of Allergy and Clinical Immunology 2013 132, 630-638DOI: (10.1016/j.jaci.2013.02.034) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Correlation between peanut protein (micrograms per gram of dust) in the infant's bed sheet and HPC (grams per week) over 1 month (A; n = 38; rs = 0.718; 95% CI, 0.517-0.843; P < .001) and 6 months (B; n = 38; rs = 0.713; 95% CI, 0.510-0.840; P < .001). Correlation between peanut protein in the infant's play area and HPC over 1 month (C; n = 38; rs = 0.732; 95% CI, 0.539-0.852; P < .001) and 6 months (D; n = 38; rs = 0.718; 95% CI, 0.517-0.843; P < .001). Axes are displayed in log scale. Journal of Allergy and Clinical Immunology 2013 132, 630-638DOI: (10.1016/j.jaci.2013.02.034) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Average HPC over 6 months (grams per week) versus peanut protein levels in the infant’s bed dust. High (>10 μg/g) peanut protein levels in the infant’s bed dust are present when both the infant and parents eat peanut (black dots). If the infant is not eating peanut, high peanut protein levels (>10 μg/g) in their bed dust is associated with moderate to high parental peanut consumption (≥10 g/week, white dots). Axes are displayed in log scale. Journal of Allergy and Clinical Immunology 2013 132, 630-638DOI: (10.1016/j.jaci.2013.02.034) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 4 Peanut protein (micrograms per gram of dust) in the infant’s bed (dark gray) and HPC (grams per week over 6 months, light gray) comparing households with reported peanut allergy in the infant (n = 8) versus reported peanut allergy in another household member (n = 5) versus no reported household member with peanut allergy (n = 32). ∗P < .05. Journal of Allergy and Clinical Immunology 2013 132, 630-638DOI: (10.1016/j.jaci.2013.02.034) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 5 Basophil activation by serial dilutions of dust samples containing low (A and C) or high (B and D) peanut protein in peanut-monoallergic (Fig 5, A and B) or nonallergic (Fig 5, C and D) patients (n = 5 pairs of sample-patient experiments). Medians, 25th and 75th percentiles, and minimum and maximum percentages of CD63+ basophils are displayed. High peanut dust extracts were dilution-adjusted to the maximum same concentration of peanut protein (10 μg/mL) and then underwent serial dilutions for comparability of dose-response, and low peanut dust samples were prepared by using the same dilution factor. Basophil activation for each concentration of peanut was compared between allergic and nonallergic children (ie, Fig 5, A, vs Fig 5, C, and Fig 5, B, vs Fig 5, D). **P < .01. Journal of Allergy and Clinical Immunology 2013 132, 630-638DOI: (10.1016/j.jaci.2013.02.034) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions