Leukocytes in glomeruli of patients with rapidly progressive GN

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Presentation transcript:

Leukocytes in glomeruli of patients with rapidly progressive GN Leukocytes in glomeruli of patients with rapidly progressive GN. High powered photomicrographs as illustrative examples of leukocytes within glomeruli in ANCA-associated GN. In all panels cell nuclei are stained with 4′,6-diamidino-2-phenylindole (blue). Leukocytes in glomeruli of patients with rapidly progressive GN. High powered photomicrographs as illustrative examples of leukocytes within glomeruli in ANCA-associated GN. In all panels cell nuclei are stained with 4′,6-diamidino-2-phenylindole (blue). (A) CD45+ cells (green, CD45 is a common leukocyte marker) in the glomerulus, (B) CD3+ T cells (green), (C) CD68+ macrophages (green), and (D) myeloperoxidase (red) expressing leukocytes (neutrophils or macrophages) in a segmental glomerular lesion with local loss of CD34 (green), an endothelial cell lesion. Nephrin (marking podocytes) is in white. Magnification: (A), (C ) and (D) x400; (B) x600. Photomicrographs from Ms. Kim O’Sullivan. A. Richard Kitching, and Holly L. Hutton CJASN 2016;11:1664-1674 ©2016 by American Society of Nephrology