MGluRIs potentiate amplitude of equilibrated NMDAR response through G-protein and Homer signaling pathways in DGCs. A, Nucleated patches excised from control.

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mGluRIs potentiate amplitude of equilibrated NMDAR response through G-protein and Homer signaling pathways in DGCs. A, Nucleated patches excised from control cell. mGluRIs potentiate amplitude of equilibrated NMDAR response through G-protein and Homer signaling pathways in DGCs. A, Nucleated patches excised from control cell. Left, Standard intracellular solution (both signaling pathways are active). Right, PeTX added to intracellular solution (only Homer pathway active). B, Nucleated patch excised from the Homer1a-overexpressing cell. Left, Standard intracellular solution (only G-protein signaling pathway active). Right, PeTX added to intracellular solution (both signaling pathways are blocked). Color codes of applied ligand cocktails and scale bars apply to A and B. Dashed line indicates time interval where response amplitude was calculated. C, Statistical summary of A and B. Response amplitudes are normalized to amplitude generated by NMDA+Gly. Significance of difference from unity: *p < 0.05; **p < 0.01; Student's t test. Inset, Fluorescent image of cultured DGC cotransfected with Homer1a and mCherry. Nathanael O'Neill et al. J. Neurosci. 2018;38:9840-9855 ©2018 by Society for Neuroscience