Integrated pharmacological preconditioning in combination with adenosine, a mitochondrial KATP channel opener and a nitric oxide donor Yuka Uchiyama,

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Date of download: 7/9/2016 Copyright © The American College of Cardiology. All rights reserved. From: Fibroblast growth factor-1 improves cardiac functional.

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Presentation transcript:

Integrated pharmacological preconditioning in combination with adenosine, a mitochondrial KATP channel opener and a nitric oxide donor Yuka Uchiyama, MD, Hajime Otani, MD, Takayuki Okada, MD, Takamichi Uchiyama, MD, Hideki Ninomiya, MD, Masakuni Kido, MD, Hiroji Imamura, MD, Shinichi Nakao, MD, Koh Shingu, MD The Journal of Thoracic and Cardiovascular Surgery Volume 126, Issue 1, Pages 148-159 (July 2003) DOI: 10.1016/S0022-5223(03)00236-8

Figure 1 Experimental protocols. Control group (n = 7) underwent 5 minutes of normothermic oxygenated potassium cardioplegia (shaded box) followed by 35 minutes of global ischemia (filled box) and 30 minutes of reperfusion. Ischemic preconditioning (IPC) group (n = 7) received 3 cycles of 5 minutes of ischemia and 5 minutes of reperfusion. Single pharmacological preconditioning (SPPC) groups (n = 7) received adenosine (Ad) or diazoxide (Dz) or S-nitroso-N-acetyl-penicillamine (SNAP) for 25 minutes. Double combination pharmacological preconditioning (DPPC) groups (n = 6) received Ad + Dz or Ad + SNAP or Dz + SNAP for 25 minutes. Triple-combination pharmacological preconditioning (TPPC) group (n = 7) received Ad + Dz + SNAP for 25 minutes. All PPC groups underwent 10 minutes of drug-free perfusion before cardioplegic arrest. In 6 groups of hearts (n = 6 each) treated with 5-hydroxydecanoate (HD) or chelerythrine (Che), these drugs were administered for 45 minutes before cardioplegic arrest with or without IPC or TPPC. The Journal of Thoracic and Cardiovascular Surgery 2003 126, 148-159DOI: (10.1016/S0022-5223(03)00236-8)

Figure 2 Left ventricular function after preconditioning and reperfusion. Isovolumic left ventricular (LV) function was measured just prior to cardioplegic arrest in the control and ischemic preconditioning (IPC) hearts. In pharmacological preconditioning (PPC), hearts with adenosine (Ad), diazoxide (Dz), and S-nitroso-N-acetyl-penicillamine (SNAP), alone or in combination with two of them or all of them, LV function was measured at the end of PPC. LV function was also measured 30 minutes after reperfusion. LVDP, HR, and CF indicate LV-developed pressure, heart rate, and coronary flow, respectively. Each bar graph represents mean ± SEM of 6 or 7 experiments. *P < .05, **P < .01 vs control. The Journal of Thoracic and Cardiovascular Surgery 2003 126, 148-159DOI: (10.1016/S0022-5223(03)00236-8)

Figure 3 Creatine kinase release during reperfusion. Coronary effluent was collected during 30 minutes of reperfusion and measured for creatine kinase release. Ischemic preconditioning (IPC) and pharmacological preconditioning with adenosine (Ad), diazoxide (Dz), and S-nitroso-N-acetyl-penicillamine (SNAP), alone or in combination with two of them or all of them, were performed according to the protocol as shown in Figure 1. Each bar graph represents mean ± SEM of 6 or 7 experiments. *P < .01 vs control. The Journal of Thoracic and Cardiovascular Surgery 2003 126, 148-159DOI: (10.1016/S0022-5223(03)00236-8)

Figure 4 Flavoprotein oxidation during ischemic preconditioning and pharmacological preconditioning. Flavoprotein fluorescence was measured as described in Materials and Methods. The upper panel shows representative traces of flavoprotein fluorescence during ischemic preconditioning (IPC) or pharmacological preconditioning with diazoxide (Dz) alone or in combination with adenosine (Ad) and S-nitroso-N-acetyl-penicillamine (SNAP) in the presence or absence of 5-hydroxydecanoate (HD). Flavoprotein oxidation was expressed as a percentage of the dinitrophenol (DNP)-induced fluorescence. Filled boxes represent ischemia and a scale bar indicates 5 minutes. The lower panel shows quantitative analysis of maximum flavoprotein oxidation. Each bar graph represents mean ± SEM of 6 experiments. **P < .01 vs IPC, ††P < .01 vs Dz, and #P < .01 vs Ad + Dz + SNAP. The Journal of Thoracic and Cardiovascular Surgery 2003 126, 148-159DOI: (10.1016/S0022-5223(03)00236-8)

Figure 5 Protein kinase C (PKC)-ϵ-selective phosphorylation activity assay. PKC-ϵ-selective phosphorylation activity after ischemic preconditioning (IPC) or pharmacological preconditioning with adenosine (Ad), diazoxide (Dz), and S-nitroso-N-acetyl-penicillamine (SNAP), in the presence or absence of 5-hydroxydecanoate (HD) or chelerythrine (Che), was measured in the particulate and the cytosol fractions as described in Materials and Methods. Each bar graph represents mean ± SEM of 6 experiments. *P < .05, **P < .01 vs control, †P < .05, ††P < .01 vs IPC, and #P < .05 vs Ad + Dz + SNAP. The Journal of Thoracic and Cardiovascular Surgery 2003 126, 148-159DOI: (10.1016/S0022-5223(03)00236-8)

Figure 6 Effect of 5-hydroxydecanoate and chelerythrine on ischemic contracture and the recovery of LV function during reperfusion. TTC indicates time to the onset of ischemic contracture. LVDP R30, HR R30, CF R30, and LVEDP R30 indicate LV-developed pressure, heart rate, coronary flow, and LV end-diastolic pressure measured at 30 minutes after reperfusion, respectively. Ischemic preconditioning (IPC) or pharmacological preconditioning with adenosine (Ad), diazoxide (Dz), and S-nitroso-N-acetyl-penicillamine (SNAP), in the presence or absence of 5-hydroxydecanoate (HD) or chelerythrine (Che), was performed according to the protocol as shown in Figure 1. Each bar graph represents mean ± SEM of 6 or 7 experiments. *P < .05, **P < .01 vs control, †P < .05, ††P < .01 vs IPC, and #P < .05, ##P < .01 vs Ad + Dz + SNAP. The Journal of Thoracic and Cardiovascular Surgery 2003 126, 148-159DOI: (10.1016/S0022-5223(03)00236-8)

Figure 7 Effect of 5-hydroxydecanoate and chelerythrine on creatine kinase release during reperfusion. Ischemic preconditioning (IPC) or pharmacological preconditioning with adenosine (Ad), diazoxide (Dz), and S-nitroso-N-acetyl-penicillamine (SNAP), in the presence or absence of 5-hydroxydecanoate (HD) or chelerythrine (Che), was performed according to the protocol as shown in Figure 1. Each bar graph represents mean ± SEM of 6 or 7 experiments. *P < .01 vs control, †P < .05 vs IPC, and #P < .05, ##P < .01 vs Ad + Dz + SNAP. The Journal of Thoracic and Cardiovascular Surgery 2003 126, 148-159DOI: (10.1016/S0022-5223(03)00236-8)