Longitudinal Assessment of Morbidity and Acute Graft-versus-Host Disease after Allogeneic Hematopoietic Cell Transplantation: Retrospective Analysis of a.

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Longitudinal Assessment of Morbidity and Acute Graft-versus-Host Disease after Allogeneic Hematopoietic Cell Transplantation: Retrospective Analysis of a Multicenter Phase III Study Fabrizio Carnevale-Schianca, Wendy Leisenring, Paul J. Martin, Terry Furlong, Gary Schoch, Claudio Anasetti, Frederick R. Appelbaum, Paul A. Carpenter, H. Joachim Deeg, Hans-Peter Kiem, Rainer Storb, George B. McDonald, Richard A. Nash Biology of Blood and Marrow Transplantation Volume 15, Issue 6, Pages 749-756 (June 2009) DOI: 10.1016/j.bbmt.2009.03.009 Copyright © 2009 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 1 A, Grade 1-4 overall morbidity for weeks 1 to 14 after HCT for all study patients. The proportion of patients with grade 1-4 overall morbidity for each week after HCT is represented by the height of the bar. The contribution of each grade of morbidity to the total is represented by different shades of the bar according to the key at the top of the figure. B, Grade I-IV acute GVHD from weeks 1 to 14 after HCT for all study patients. The proportion of patients with overall grade I-IV acute GVHD is represented by the height of the bar for each week after transplantation. The contribution of each grade of GVHD to the total is represented by different shades of the bar according to the key at the top of the figure. Comparing A and B shows that the proportion of patients with grade 1-4 overall morbidity is substantially greater than the proportion of patients with grade I-IV acute GVHD, especially in the first weeks after HCT but continuing to a lesser degree to week 14. The numbers at the top of each bar in the graph of both figures represent the number of subjects available for the analysis at each of the weekly time points. Biology of Blood and Marrow Transplantation 2009 15, 749-756DOI: (10.1016/j.bbmt.2009.03.009) Copyright © 2009 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 2 Grade 1-4 overall morbidity for weeks 1 to 14 after HCT for patients with peak grade 0-II acute GVHD (A) and peak grade III-IV acute GVHD (B). The differences in morbidity between grade 0-II and grade III-IV acute GVHD are most apparent after week 5. Early morbidity in both groups resulted from regimen-related toxicity. The numbers at the top of each bar in the graph represent the number of subjects available for the analysis at each of the weekly time points. Biology of Blood and Marrow Transplantation 2009 15, 749-756DOI: (10.1016/j.bbmt.2009.03.009) Copyright © 2009 American Society for Blood and Marrow Transplantation Terms and Conditions