Chia-Wei Cheng, Ömer H. Yilmaz Cell Stem Cell

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Presentation transcript:

FAOund the Link: Phospholipid Remodeling and Intestinal Stem Cell Growth and Tumorigenesis Chia-Wei Cheng, Ömer H. Yilmaz Cell Stem Cell Volume 22, Issue 2, Pages 141-143 (February 2018) DOI: 10.1016/j.stem.2018.01.009 Copyright © 2018 Elsevier Inc. Terms and Conditions

Figure 1 Cholesterols and Membrane Composition Drive ISC Proliferation and Tumorigenesis (A) In Lpcat3 wild-type mice (WT), active phospholipid-remodeling enzyme Lpcat3 maintains membrane integrity, basal cholesterol biosynthesis, and proliferation in intestinal crypt cells and tumors. Dietary cholesterols promote the proliferation of both intestinal crypt cells and tumors. (B) In Lpcat3 knockout mice (KO), Lpcat3 deficiency impairs phospholipid remodeling and induces cholesterol biosynthesis, leading to hyperproliferation of intestinal crypt cells and tumors. Ro 48-8071 (Ro48, LSS inhibitor) blocks cholesterol biosynthesis and reduces the hyperproliferation of intestinal crypt cells and tumor growth. Cell Stem Cell 2018 22, 141-143DOI: (10.1016/j.stem.2018.01.009) Copyright © 2018 Elsevier Inc. Terms and Conditions