The complexity of obstructive sleep apnoea (OSA) for consideration in a personalised medicine approach. The complexity of obstructive sleep apnoea (OSA) for consideration in a personalised medicine approach. PSG: polysomnography; GWA: genome-wide association; EDS: excessive daytime sleepiness; PALM: Pcrit (passive critical closing pressure), arousal threshold, loop gain and muscle responsiveness; CCC: complete concentric palatal collapse; IL: interleukin; HTN: systemic hypertension. Reproduced and modified from [18] with permission. Maria R. Bonsignore et al. Eur Respir Rev 2017;26:170069 ©2017 by European Respiratory Society