Fig. 4 Skin test response to peptide cocktails in field reactors.

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Fig. 4 Skin test response to peptide cocktails in field reactors. Skin test response to peptide cocktails in field reactors. (A) Peptide cocktails, PCL and PC-1, alongside PPD-A and PPD-B, were tested in naturally infected animals identified in Ethiopia (n = 25). Results are expressed as the difference in skin thickness (in millimeters) between the pre- and post-skin test readings, with the horizontal line providing the median (±95% CI). Positivity is defined as ≥2 mm for PCL and PC-1, and ≥4 mm for PPD(B-A) and PPD-B (denoted by the solid lines). The statistical difference between PCL and PC-1 responses was determined by using two-tailed t test (**P < 0.01). (B) The relative sensitivity of the peptide cocktails, SIT, and SICCT was calculated. (C) Animals represented by open red circles are positive by PCL only, closed blue circles are positive by PPD(B-A) only, open blue circles are negative on both, and closed red circles are positive on both. The peptide cocktail, PCL, identified nine (36%) presumed infected animals that were not detected by the standard SICCT. Sreenidhi Srinivasan et al. Sci Adv 2019;5:eaax4899 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY).