Volume 6, Issue 8, Pages (August 1998)

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Volume 6, Issue 8, Pages 1047-1055 (August 1998) Involvement of the C terminus in intramolecular nitrogen channeling in glucosamine 6- phosphate synthase: evidence from a 1.6 å crystal structure of the isomerase domain Alexei Teplyakov, Galya Obmolova, Marie-Ange Badet-Denisot, Bernard Badet, Igor Polikarpov Structure Volume 6, Issue 8, Pages 1047-1055 (August 1998) DOI: 10.1016/S0969-2126(98)00105-1

Figure 1 Residues 418 and 419 are modelled as lysine and leucine, respectively, and not as asparagine and valine, as the DNA sequence suggests. The figure shows the (3Fo–2Fc) electron density at residues Lys418 and Leu419 contoured at 1.5σ. Structure 1998 6, 1047-1055DOI: (10.1016/S0969-2126(98)00105-1)

Figure 2 Ribbon representation of the isomerase domain of GlmS. The approximate twofold axis is horizontal. Secondary structural elements (β strands, red; α helices, green) are labelled. The C tail is shown in cyan. Glucosamine-6P and MES are shown as ball-and-stick models. The fragment with helix CE# belongs to the neighbouring monomer. Structure 1998 6, 1047-1055DOI: (10.1016/S0969-2126(98)00105-1)

Figure 3 Amino-acid sequence and secondary structural elements of the isomerase domain of GlmS. Helices are shown as boxes (CG and CE are 310 helices, others are α helices) and β strands as arrows. Invariant residues are marked by asterisks. Structure 1998 6, 1047-1055DOI: (10.1016/S0969-2126(98)00105-1)

Figure 4 Glucosamine-6P in the cyclic form is bound at the C-terminal edge of the β sheet of the N-terminal subdomain. The figure shows (3Fo–2Fc) electron density at glucosamine-6P contoured at 1.5σ. Structure 1998 6, 1047-1055DOI: (10.1016/S0969-2126(98)00105-1)

Figure 5 Stereoview of the active site of the isomerase domain with bound glucosamine-6P (open lines). Hydrogen bonds are indicated by dashed lines. Residues are labelled using the single-letter amino acid code; water molecules are indicated by numbers only. Structure 1998 6, 1047-1055DOI: (10.1016/S0969-2126(98)00105-1)

Figure 6 Dimer of the isomerase domains as viewed along the crystallographic twofold axis. Helices involved in the intersubunit contacts are labelled. Glucosamine-6P molecules are represented by ball-and-stick models. Different polypeptide chains are coloured blue and yellow, with the β sheets highlighted. Structure 1998 6, 1047-1055DOI: (10.1016/S0969-2126(98)00105-1)