PTZ-induced neuronal activity visualized by IEGs

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PTZ-induced neuronal activity visualized by IEGs PTZ-induced neuronal activity visualized by IEGs. WT (white bars) and CS/CS (black bars) mice received a single injection of PTZ at a dose of 0, 20, 40, or 60 mg/kg and fixed 2 h after PTZ administration. PTZ-induced neuronal activity visualized by IEGs. WT (white bars) and CS/CS (black bars) mice received a single injection of PTZ at a dose of 0, 20, 40, or 60 mg/kg and fixed 2 h after PTZ administration. Brain sections were incubated with each antibody and DAPI. Typical images are shown as representative (left). Scale bar, 200 μm. Ratio of c-Fos or Arc-positive to DAPI-positive cells are shown (right). White broken lines indicate the edge of lateral ventricle. A, c-Fos expression in the hippocampal dentate gyrus (n = 5, respectively, F(7,32) = 10.58, p < 0.0001). B, Arc expression in the hippocampal dentate gyrus (n = 6, respectively, F(7,40) = 14.22, p < 0.0001). C, c-Fos expression in the cortex (n = 19, respectively, F(7,144) = 12.44, p < 0.0001). D, Arc expression in the cortex (n = 12, respectively, F(7,88) = 3.166, p = 0.0049). Error bars indicate SEM. ANOVA with Tukey post hoc test. *p < 0.05, **p < 0.01, ***p < 0.001 compared with WT controls. See also Extended Figure 7-1. Masayuki Itoh et al. J. Neurosci. 2018;38:10220-10235 ©2018 by Society for Neuroscience