Heparin-induced platelet activation: The role of thromboxane A2 synthesis and the extent of platelet granule release in two patients Jeffrey R. Kappa,

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Presentation transcript:

Heparin-induced platelet activation: The role of thromboxane A2 synthesis and the extent of platelet granule release in two patients Jeffrey R. Kappa, MD a, Carol A. Fisher, AB, V.Paul Addonizio, MD b Journal of Vascular Surgery Volume 9, Issue 4, Pages 574-579 (April 1989) DOI: 10.1016/0741-5214(89)90475-8 Copyright © 1989 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 1 Percent of total releasable 14C-serotonin (dense granule) (??), PF4 (alpha granule) (??), and N-acetyl-β-glucosaminidase (lysosomal granule) (??) after heparin challenge is plotted in bar form. Aspirin, iloprost, and heparin have been added to 500 mm3 of the patients' plateletrich plasma to achieve final concentrations of 4 mmol/L, 0.01 μmol/L and 3 U/ml, respectively. Journal of Vascular Surgery 1989 9, 574-579DOI: (10.1016/0741-5214(89)90475-8) Copyright © 1989 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 2 Percent platelet aggregation (□) and total releasable TxB2 generation (??) after heparin challenge is plotted in bar form. Otherwise legend is identical to that of Fig. 1. Journal of Vascular Surgery 1989 9, 574-579DOI: (10.1016/0741-5214(89)90475-8) Copyright © 1989 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions