A. Khwaja, C.C. Sharpe, M. Noor, B.M. Hendry Kidney International

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The role of geranylgeranylated proteins in human mesangial cell proliferation A. Khwaja, C.C. Sharpe, M. Noor, B.M. Hendry Kidney International Volume 70, Issue 7, Pages 1296-1304 (October 2006) DOI: 10.1038/sj.ki.5001713 Copyright © 2006 International Society of Nephrology Terms and Conditions

Figure 2 Study of apoptosis. (a, c) Proapoptotic effects of 10μM lovastatin and (b, d) 10–20μM GGTI 298 in serum- and PDGF-stimulated HMCs. Apoptosis was determined by Hoechst 33342 and propidium iodide staining. Co-incubation of lovastatin with 7.5μM GGPP reduces the proapoptoic effects of lovastatin. The error bars are s.e.m., n=3. *P<0.05 and ***P<0.001 with respect to vehicle-treated cells. Kidney International 2006 70, 1296-1304DOI: (10.1038/sj.ki.5001713) Copyright © 2006 International Society of Nephrology Terms and Conditions