Myocardial remodeling with aortic stenosis and after aortic valve replacement: Mechanisms and future prognostic implications William M. Yarbrough, MD,

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Presentation transcript:

Myocardial remodeling with aortic stenosis and after aortic valve replacement: Mechanisms and future prognostic implications William M. Yarbrough, MD, Rupak Mukherjee, PhD, John S. Ikonomidis, MD, PhD, Michael R. Zile, MD, Francis G. Spinale, MD, PhD The Journal of Thoracic and Cardiovascular Surgery Volume 143, Issue 3, Pages 656-664 (March 2012) DOI: 10.1016/j.jtcvs.2011.04.044 Copyright © 2012 Terms and Conditions

Figure 1 Villari and colleagues6 demonstrated that regression of AS-induced cellular and extracellular abnormalities occurs in a time-dependent manner after AVR. Moreover, elimination of the pressure overload state failed to achieve normalization of myocyte diameter and interstitial fibrosis. Expressed as a percentage change from control values, AVR was associated with significant reductions in muscle fiber diameter at both early (22 ± 8 months) and late (81 ± 24 months) time points compared with preoperative values; however, muscle fiber diameter remained significantly elevated over control values late after AVR. Values for interstitial fibrosis increased early after AVR compared with preoperative values. This increase was likely “relative” and a result of a concomitant early reduction in myocyte mass as opposed to an increase in collagen synthesis after AVR. Values for interstitial fibrosis remained significantly elevated above those observed in the control group late after AVR. Data are presented as the mean and the standard error of the mean and were modified from Villari and colleagues6 (∗P < .05 vs control, +P < .05 vs preoperative, #P < .05 vs early). The Journal of Thoracic and Cardiovascular Surgery 2012 143, 656-664DOI: (10.1016/j.jtcvs.2011.04.044) Copyright © 2012 Terms and Conditions

Figure 2 Increasing degrees of myocardial fibrosis secondary to aortic valve disease (as assessed histologically) are associated with progressive reductions in survival in patients treated with AVR using traditional criteria for intervention (ie, symptom onset). Modified from Azevedo and colleagues.13 The Journal of Thoracic and Cardiovascular Surgery 2012 143, 656-664DOI: (10.1016/j.jtcvs.2011.04.044) Copyright © 2012 Terms and Conditions

Figure 3 The hypothetic schematic depicts deterioration in diastolic function and an increase in myocyte hypertrophy and myocardial fibrosis over time and in the setting of AS-induced progressive pressure overload. Current management paradigms advocate AVR for patients with severe AS and associated symptoms, namely, angina, syncope, and chronic heart failure. However, AVR carried out only after symptom onset likely fails to reverse the maladaptive ECM remodeling that has already occurred. Identification of a biomarker capable of heralding the transition from AS-induced adaptive to maladaptive ECM remodeling processes may have therapeutic value. Specifically, identification of such a biomarker may be used to direct more timely elimination of the pressure overload state, thus optimizing the chances for normalization within the ECM and improved postoperative outcomes. AS, Aortic stenosis; AV, aortic valve; AVR, aortic valve replacement; ECM, extracellular matrix; LVH, left ventricular hypertrophy. The Journal of Thoracic and Cardiovascular Surgery 2012 143, 656-664DOI: (10.1016/j.jtcvs.2011.04.044) Copyright © 2012 Terms and Conditions