David J Chambers, PhD, David J Hearse, DSc

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Presentation transcript:

Developments in cardioprotection: “polarized” arrest as an alternative to “depolarized” arrest David J Chambers, PhD, David J Hearse, DSc The Annals of Thoracic Surgery Volume 68, Issue 5, Pages 1960-1966 (November 1999) DOI: 10.1016/S0003-4975(99)01020-6

Fig 1 Postischemic recovery of developed pressure (expressed as a percent of preischemic control function) in hearts subjected to 15 minute unprotected normothermic (37°C) global ischemia, a 50 ml infusion (at 4°C) of either Krebs Henseleit buffer (KH) alone (control), St. Thomas’ Hospital (STH2) cardioplegic solution, or KH plus 50 μM pinacidil followed by 50 minutes hypothermic (15°C) global ischemia before being reperfused for 30 minutes. Values are shown as mean ± standard error of the mean; ∗p < 0.05 compared to the KH group. Redrawn from Lawton and associates [39]. The Annals of Thoracic Surgery 1999 68, 1960-1966DOI: (10.1016/S0003-4975(99)01020-6)

Fig 2 Postischemic recovery of aortic flow (expressed as a percent of preischemic control function) in hearts arrested and stored for 5 hours with Krebs Henseleit buffer (KH) alone, KH containing 16 mM K+, or KH containing 22 μM tetrodotoxin (TTX). Values are shown as mean ± standard error of the mean; ∗p < 0.05 compared to the KH group, ∗∗p < 0.05 compared to the KH + 16 mM K+ group. Redrawn from Snabaitis and associates [46]. The Annals of Thoracic Surgery 1999 68, 1960-1966DOI: (10.1016/S0003-4975(99)01020-6)

Fig 3 Cardiac resting membrane potential (Em) recorded every 15 minutes throughout 5 hours of hypothermic (7.5°C) ischemic arrest. Solid triangles represent ischemic arrest, solid circles represent depolarized arrest, and solid squares represent polarized arrest. Values are shown as mean ± standard error of the mean. Redrawn from Snabaitis and associates [46]. The Annals of Thoracic Surgery 1999 68, 1960-1966DOI: (10.1016/S0003-4975(99)01020-6)