Neurons Are the Inflammatory Problem Kevin J. Tracey  Cell  Volume 173, Issue 5, Pages 1066-1068 (May 2018) DOI: 10.1016/j.cell.2018.05.005 Copyright © 2018 Terms and Conditions

Figure 1 Bacterial Toxins Stimulate Neurons to Secrete Neuropeptides that in Turn Inhibit the Ability of Neutrophils to Kill the Bacteria Streptococcus pyogenes on skin gains access to the fascial plane between (in this case) subcutaneous tissue and muscle. TRPV1 nocioceptive neurons are stimulated by the exotoxin streptolysin S to transmit axon reflexes. This is the basis of intense pain, the cardinal feature of necrotizing fasciitis. In addition, action potentials in these same neurons return as axon reflexes to distal nerve endings that secrete calcitonin gene-related peptide (CGRP). This neuropeptide inhibits neutrophil activity against the invading pathogen. The result is that pathogens replicate relatively unscathed against innate immune responses and disseminate rapidly along the fascial planes’ deep tissue, causing massive necrosis and destruction. Cell 2018 173, 1066-1068DOI: (10.1016/j.cell.2018.05.005) Copyright © 2018 Terms and Conditions