Innate immune defects correlate with failure of antibody responses to H1N1/09 vaccine in HIV-infected patients Suresh Pallikkuth, PhD, Sudheesh Pilakka.

Slides:

Advertisements

Similar presentations

Peripheral T follicular Helper Cells (pTfh)

Advertisements

Control of immunopathology during chikungunya virus infection Caroline Petitdemange, PhD, Nadia Wauquier, PhD, Vincent Vieillard, PhD Journal of Allergy.

Defective B-cell memory in patients with Down syndrome Ruud H.J. Verstegen, MD, Gertjan J. Driessen, MD, Sophinus J.W. Bartol, BSc, Carel J.M. van Noesel,

Differentiation stage determines pathologic and protective allergen-specific CD4+ T-cell outcomes during specific immunotherapy Erik Wambre, PhD, Jonathan.

Comparison of the allergic and nonallergic CD4+ T-cell responses to the major dog allergen Can f 1 Suvi Parviainen, MSc, Antti Taivainen, MD, PhD, Aino.

The human polysaccharide- and protein-specific immune response to Streptococcus pneumoniae is dependent on CD4+ T lymphocytes, CD14+ monocytes, and the.

Tetanus immunity after diphtheria, tetanus toxoids, and acellular pertussis vaccination in children with clinically stable HIV infection Howard M. Rosenblatt,

Premature immune senescence during HIV-1 vertical infection relates with response to influenza vaccination Alberto Cagigi, PhD, Stefano Rinaldi, MSc,

High-titer IgE antibody specific for pollen allergens in northern California is associated with both wheezing and total serum IgE Elizabeth A. Erwin,

Premature immune senescence during HIV-1 vertical infection relates with response to influenza vaccination Alberto Cagigi, PhD, Stefano Rinaldi, MSc,

Advances in food allergy in 2015

Santa Jeremy Ono, BA, PhD, Mark B. Abelson, MD

Atopic dermatitis: Age and race do matter!

Birch pollen immunotherapy results in long-term loss of Bet v 1–specific TH2 responses, transient TR1 activation, and synthesis of IgE-blocking antibodies

Is 9 more than 2 also in allergic airway inflammation?

The enigma of IgE+ B-cell memory in human subjects

Lieuwe D. Bos, MSc, PhD, Peter J. Sterk, MD, PhD, Stephen J

Yuichi Teraki, MD, Aika Sakurai, MD, Seiichi Izaki, MD

Kathleen R. Bartemes, BA, Gail M. Kephart, BS, Stephanie J

Peter M. Wolfgram, MD, David B. Allen, MD

Toll-like receptor 9, transmembrane activator and calcium-modulating cyclophilin ligand interactor, and CD40 synergize in causing B-cell activation Esra.

Allison K. Martin, BS, Douglas G. Mack, PhD, Michael T

Jewlya Lynn, PhD, Sophie Oppenheimer, MS, MPH, Lorena Zimmer, MA

Chronic cat allergen exposure induces a TH2 cell–dependent IgG4 response related to low sensitization Amedee Renand, PhD, Luis D. Archila, MSc, John.

Thymic stromal lymphopoietin–activated invariant natural killer T cells trigger an innate allergic immune response in atopic dermatitis Wen Hao Wu, PhD,

Ricardo U. Sorensen, MD, Luke A. Wall, MD

Time for a paradigm shift in asthma treatment: From relieving bronchospasm to controlling systemic inflammation Leif Bjermer, MD Journal of Allergy.

Serum free light chains in the differential diagnosis and prognosis of primary and secondary hypogammaglobulinemia Nicolò Compagno, MD, Francesco Cinetto,

Food allergy: A review and update on epidemiology, pathogenesis, diagnosis, prevention, and management Scott H. Sicherer, MD, Hugh A. Sampson, MD Journal.

Biosimilars and drug development in allergic and immunologic diseases

Daphne Koinis-Mitchell, PhD, Timothy Craig, DO, Cynthia A

Differentiation stage determines pathologic and protective allergen-specific CD4+ T-cell outcomes during specific immunotherapy Erik Wambre, PhD, Jonathan.

CC chemokine receptors CCR1 and CCR4 are expressed on airway mast cells in allergic asthma Kawa Amin, PhD, Christer Janson, MD, PhD, Ilkka Harvima, MD,

What is an “eosinophilic phenotype” of asthma?

The L412F variant of Toll-like receptor 3 (TLR3) is associated with cutaneous candidiasis, increased susceptibility to cytomegalovirus, and autoimmunity

Liam O’Mahony, PhD, Mübeccel Akdis, MD, PhD, Cezmi A. Akdis, MD

Opsonic function of bronchoalveolar lavage IgG after pneumococcal vaccination in HIV- infected and uninfected adults Jerry C.H. Tam, Nicola L. Grant,

Direct ex vivo analysis of allergen-specific CD4+ T cells

Determination of IgG subclasses: A need for standardization

Autophagy: Nobel Prize 2016 and allergy and asthma research

IL-2– and CD25-dependent immunoregulatory mechanisms in the homeostasis of T-cell subsets Sven Létourneau, DPhil, Carsten Krieg, PhD, Giuseppe Pantaleo,

Innate immune responses to rhinovirus are reduced by the high-affinity IgE receptor in allergic asthmatic children Sandy R. Durrani, MD, Daniel J. Montville,

Advances in the approach to the patient with food allergy

Luisa Lunardon, MD, Aimee S. Payne, MD, PhD

The human polysaccharide- and protein-specific immune response to Streptococcus pneumoniae is dependent on CD4+ T lymphocytes, CD14+ monocytes, and the.

Influence of cytomegalovirus infection on immune cell phenotypes in patients with common variable immunodeficiency Sayed Mahdi Marashi, PhD, Mohammed.

Cagri Yildirim-Toruner, MD, Betty Diamond, MD

Benjamin Chaigne, MD, Hervé Watier, MD, PhD

Xiu-Min Li, MD, LaVerne Brown, PhD

Thymic output markers indicate immune dysfunction in DiGeorge syndrome

In vivo effects of glucocorticoids on IgE production

Innate immune responses to infection

Usa Tantibhaedhyangkul, MD, Carla M. Davis, MD, Lenora M

Advances in basic and clinical immunology in 2013

Tetanus immunity after diphtheria, tetanus toxoids, and acellular pertussis vaccination in children with clinically stable HIV infection Howard M. Rosenblatt,

Immune response to varicella vaccine in children with atopic dermatitis compared with nonatopic controls Lynda Schneider, MD, Adriana Weinberg, MD, Mark.

CD25 deficiency causes an immune dysregulation, polyendocrinopathy, enteropathy, X- linked–like syndrome, and defective IL-10 expression from CD4 lymphocytes

Macrolide antibiotics and asthma treatment

Immune pathomechanism of drug hypersensitivity reactions

Asthma: The past, future, environment, and costs

Julie Negri, BA, S. Brandon Early, BA, John W

Placental transfer of allergen-specific IgG but not IgE from a specific immunotherapy– treated mother Sabine Flicker, PhD, Katharina Marth, MD, Heinz.

Janet Chou, MD, Maxim Lutskiy, MD, PhD, Erdyni Tsitsikov, PhD, Luigi D

Functional assessment of pathogenic IgG subclasses in chronic autoimmune urticaria Sridharan Soundararajan, PhD, Yoko Kikuchi, DVM, Kusumam Joseph, PhD,

IgG4 production is confined to human IL-10–producing regulatory B cells that suppress antigen-specific immune responses Willem van de Veen, MSc, Barbara.

Environmental factors and eosinophilic esophagitis

Validation of current joint American Academy of Allergy, Asthma & Immunology and American College of Allergy, Asthma and Immunology guidelines for antibody.

Natural history of cow’s milk allergy

Primary prevention of asthma and allergy

Comparison of the allergic and nonallergic CD4+ T-cell responses to the major dog allergen Can f 1 Suvi Parviainen, MSc, Antti Taivainen, MD, PhD, Aino.

Presentation transcript:

Innate immune defects correlate with failure of antibody responses to H1N1/09 vaccine in HIV-infected patients Suresh Pallikkuth, PhD, Sudheesh Pilakka Kanthikeel, PhD, Sandra Y. Silva, MD, Margaret Fischl, MD, Rajendra Pahwa, MD, Savita Pahwa, MD Journal of Allergy and Clinical Immunology Volume 128, Issue 6, Pages 1279-1285 (December 2011) DOI: 10.1016/j.jaci.2011.05.033 Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 H1N1/09 Rs show expansion of memory B cells: frequencies of memory B cells (CD20+ CD27+ CD10−) in total (CD20+) B cells (A), KI67+ memory B cells (B), and IgG-producing ASCs (C) following ex vivo stimulation with H1N1 antigen. Journal of Allergy and Clinical Immunology 2011 128, 1279-1285DOI: (10.1016/j.jaci.2011.05.033) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Serum BAFF and APRIL levels are increased in H1N1/09 R patients: Serum levels of BAFF and APRIL were measured by ELISA. A, Serum levels of BAFF. B, Serum levels of APRIL. Journal of Allergy and Clinical Immunology 2011 128, 1279-1285DOI: (10.1016/j.jaci.2011.05.033) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Differential expression of BAFF-R and TACI in R and NR patients: representative histograms showing frequency of BAFF-R (A) and TACI (D) in total B cells at T0 (gray) and T2 (black) compared with isotype controls (filled). Expression of BAFF-R+ in total B cells (B) and memory B cells (C). TACI expression in total B cells (E) and memory B cells (F). Correlation between the H1N1 Ab titer with BAFF-R+ B cells (G) and TACI+ B cells (H). Journal of Allergy and Clinical Immunology 2011 128, 1279-1285DOI: (10.1016/j.jaci.2011.05.033) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 4 H1N1 antigen-stimulated IL-2, IFNγ, and IgG responses in HCs and HIV-infected patients pre- and post-H1N1 vaccination: frequencies of H1N1-stimulated IFN-γ (A) and IL-2–producing SFUs (B) in PBMCs at T0 and T2. C, Correlation between the H1N1 Ab titer and IL-2 SFUs in PBMC ELISpot assay. D, Mean H1N1-stimulated IgG ASCs with and without exogenous IL-2 at T0 and T2. Journal of Allergy and Clinical Immunology 2011 128, 1279-1285DOI: (10.1016/j.jaci.2011.05.033) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions