Brain selective uptake of CE from plasma HDL

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Brain selective uptake of CE from plasma HDL Brain selective uptake of CE from plasma HDL. Control (n = 4) and Abca1−B/−B (n = 5) mice were injected with HDL particles labeled with 125I-TC in the apolipoprotein and 3H-CEt in the CE moiety, respectively, and plasma clearance and tissue uptake of 125I-T... Brain selective uptake of CE from plasma HDL. Control (n = 4) and Abca1−B/−B (n = 5) mice were injected with HDL particles labeled with 125I-TC in the apolipoprotein and 3H-CEt in the CE moiety, respectively, and plasma clearance and tissue uptake of 125I-TC and 3H-CEt were measured. Data are shown as means ± SEM. A, Fraction of 3H and 125I activity remaining in plasma at 24 h. B, Brain uptake rate, measured by brain FCR, of 3H-CEt and 125I-TC. C, Selective brain 3H-CE uptake rate. D, Regression analysis of correlation between the fraction of 3H cpm left in plasma at 24 h and brain 3H-CE uptake (black boxes: control mice, gray triangles: Abca1−B/−B mice). *p < 0.05, **p < 0.01 compared with control mice. Joanna M. Karasinska et al. J. Neurosci. 2009;29:3579-3589 ©2009 by Society for Neuroscience