Physiology of the (pro)renin receptor: Wnt of change?

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Presentation transcript:

Physiology of the (pro)renin receptor: Wnt of change? Gabin Sihn, Anthony Rousselle, Larissa Vilianovitch, Celine Burckle, Michael Bader Kidney International Volume 78, Issue 3, Pages 246-256 (August 2010) DOI: 10.1038/ki.2010.151 Copyright © 2010 International Society of Nephrology Terms and Conditions

Figure 1 Functions of (P)RR/ATP6ap2. For details see text. ACE, angiotensin-converting enzyme; AOG, angiotensinogen; ER, endoplasmic reticulum; HRP, handle region peptide; MAPK, mitogen-activated protein kinase; PLZF, promyelocytic leukemia zinc finger. Kidney International 2010 78, 246-256DOI: (10.1038/ki.2010.151) Copyright © 2010 International Society of Nephrology Terms and Conditions

Figure 2 Expression of (P)RR/ATP6ap2 in different rat organs. Expression of (P)RR/ATP6ap2 was assessed in different organs of male and female Sprague–Dawley rats by RNase protection assay using each 20 μg total RNA with specific probes for rat (P)RR/ATP6ap2 and β-actin. Kidney International 2010 78, 246-256DOI: (10.1038/ki.2010.151) Copyright © 2010 International Society of Nephrology Terms and Conditions

Figure 3 Attempts to generate (P)RR/ATP6ap2-knockout mice. (a) Number of pregnant mice, pups, and chimeras obtained after blastocyst injection of (P)RR/ATP6ap2-knockout ES cells (RST307 from BayGenomics, http://baygenomics.ucsf.edu) and re-implantation into foster mothers (C57Bl/6); no knockout mouse was obtained subsequent to the breeding of the only chimera. (b) Aspect of the only chimera, displaying very low chimerism in the fur (arrowhead). (c) As comparison, a control chimera obtained with non-modified ES cells with similar procedures displaying 70–80% chimerism and germ line transmission. Kidney International 2010 78, 246-256DOI: (10.1038/ki.2010.151) Copyright © 2010 International Society of Nephrology Terms and Conditions