Regulation of ENaCs by proteases: An increasingly complex story

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Regulation of ENaCs by proteases: An increasingly complex story T.R. Kleyman, M.M. Myerburg, R.P. Hughey Kidney International Volume 70, Issue 8, Pages 1391-1392 (October 2006) DOI: 10.1038/sj.ki.5001860 Copyright © 2006 International Society of Nephrology Terms and Conditions

Figure 1 ENaC is activated by proteolytic cleavage. ENaC is cleaved by furin twice in the α subunit and once in the γ subunit. The β subunit is not cleaved. ENaC is activated and is probably cleaved by other proteases, such as prostasin, that are inhibited by protease nexin-1 (PN-1). Kidney International 2006 70, 1391-1392DOI: (10.1038/sj.ki.5001860) Copyright © 2006 International Society of Nephrology Terms and Conditions