Effects of pain-stress on striatal dopamine release as a function of HTR2C genotype. Effects of pain-stress on striatal dopamine release as a function.

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Effects of pain-stress on striatal dopamine release as a function of HTR2C genotype. Effects of pain-stress on striatal dopamine release as a function of HTR2C genotype. A, Stress-induced dopamine release, expressed as percentage change in D2/D3 binding potential (BPND) relative to baseline, in three striatal regions of interest. Positive change represents pain-induced decrease in BPND, which reflects dopamine release. Error bars indicate SEM. B, Nucleus accumbens, caudate nucleus, and putamen regions of interest are shown over a coronal MRI section in standardized space (y = 10). C, Stress-induced dopamine release versus HTR2C genotype for the 3-group classification. Brian J. Mickey et al. J. Neurosci. 2012;32:9344-9350 ©2012 by Society for Neuroscience