Volume 65, Issue 6, Pages (June 2004)

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Volume 65, Issue 6, Pages 2184-2192 (June 2004) In vitro study of the potential role of guanidines in leukocyte functions related to atherogenesis and infection Griet L. Glorieux, Annemieke W. Dhondt, Peter Jacobs, Joke Van Langeraert, Norbert H. Lameire, Peter Paul De Deyn, Raymond C. Vanholder Kidney International Volume 65, Issue 6, Pages 2184-2192 (June 2004) DOI: 10.1111/j.1523-1755.2004.00631.x Copyright © 2004 International Society of Nephrology Terms and Conditions

Figure 1 Representative time curves of luminal-dependent chemiluminescence (CL) assay from phorbol-myristate-acetate (PMA)-stimulated HL-60 cells. The cells were cultured in medium, in medium supplemented with guanidino compounds [methylguanidine (MG), guanidine (G), creatinine (CTN), guanidinoacetic acid (GAA), and guanidinosuccinic acid (GSA)] both in the absence and the presence of calcitriol (C). Calcitriol-treated cells are to be considered as the equivalent of monocyte/macrophage cells. In parallel to the average results illustrated in Table 2, there is a marked decrease in response of the calcitriol-treated cells in the presence of methylguanidine and a less marked inhibition in the presence of guanidino acetic acid and guanidinosuccinic acid. Guanidine, in contrast, has a stimulatory effect. The impact of creatinine is neutral. Kidney International 2004 65, 2184-2192DOI: (10.1111/j.1523-1755.2004.00631.x) Copyright © 2004 International Society of Nephrology Terms and Conditions

Figure 2 Evaluation of the lipopolysaccharide (LPS)-stimulated intracellular tumor necrosis factor-α (TNF-α) production by monocytes after incubation of whole blood. The evaluation was performed n the presence of methylguanidine (MG), guanidine (G), creatinine (CTN), guanidinoacetic acid (GAA), and guanidinosuccinic acid (GSA) compared to saline. *P < 0.05 versus saline (N - 8). Kidney International 2004 65, 2184-2192DOI: (10.1111/j.1523-1755.2004.00631.x) Copyright © 2004 International Society of Nephrology Terms and Conditions