Hippocampus formation: An intriguing collaboration

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Hippocampus formation: An intriguing collaboration Henk Roelink  Current Biology  Volume 10, Issue 7, Pages R279-R281 (April 2000) DOI: 10.1016/S0960-9822(00)00407-3

Figure 1 Diagrams of the dorsal left cerebral hemisphere of (a) wild-type, (b)Lef1−/− and (c)Wnt3a−/− or Lef1–LacZ/Lef1–LacZ mouse embryos. In (a), the hippocampus, transitional cortex and neocortex are indicated. In Lef1−/− mice (b), the typical ‘S’ shape of the hippocampus can still be seen, but the dentate gyrus is absent. The phenotypes of Wnt3a−/− and Lef1–LacZ/Lef1–LacZ mice (c) are similar and characterized by the absence of the hippocampus. Multilayered neocortical structures can be observed at the position that would normally be occupied by the hippocampus. Current Biology 2000 10, R279-R281DOI: (10.1016/S0960-9822(00)00407-3)