Vitamin D in allergic disease: Shedding light on a complex problem

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Presentation transcript:

Vitamin D in allergic disease: Shedding light on a complex problem Beda Muehleisen, MD, Richard L. Gallo, MD, PhD Journal of Allergy and Clinical Immunology Volume 131, Issue 2, Pages 324-329 (February 2013) DOI: 10.1016/j.jaci.2012.12.1562 Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Overview of vitamin D and its interactions with cells of the immune system. Vitamin D3 intake is the combination of dietary consumption and UV exposure. After 25- hydroxylation of vitamin D3 in the liver, the serum 25OH-D3 value is a good indicator of the level of intake. The optimal value for serum 25OH-D3 remains a point of controversy. Hydroxylation of 25OH-D3 to 1,25OH-D3 occurs mainly in the kidney, but this step also occurs on peripheral cells, enabling rapid fine control of the activation of vitamin D in immune cells. Laboratory evidence suggests 1,25(OH)2-D3 can affect the function of a wide range of immunocytes, generally enhancing innate defense mechanisms and inhibiting inflammatory events. Journal of Allergy and Clinical Immunology 2013 131, 324-329DOI: (10.1016/j.jaci.2012.12.1562) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions