Nitrosative stress in the bronchial mucosa of severe chronic obstructive pulmonary disease Fabio L.M. Ricciardolo, MD, Gaetano Caramori, MD, PhD, Kazuhiro.

Slides:

Advertisements

Similar presentations

Control of immunopathology during chikungunya virus infection Caroline Petitdemange, PhD, Nadia Wauquier, PhD, Vincent Vieillard, PhD Journal of Allergy.

Advertisements

Endoplasmic reticulum stress influences bronchial asthma pathogenesis by modulating nuclear factor κB activation So Ri Kim, MD, PhD, Dong Im Kim, MS, Mi.

D-dimer: A biomarker for antihistamine-resistant chronic urticaria

Premature immune senescence during HIV-1 vertical infection relates with response to influenza vaccination Alberto Cagigi, PhD, Stefano Rinaldi, MSc,

Simultaneously increased fraction of exhaled nitric oxide levels and blood eosinophil counts relate to increased asthma morbidity Andrei Malinovschi,

Obesity and pulmonary function testing

Anne M. Fitzpatrick, PhD, MSCR, W. Gerald Teague, MD

Pharmacologic rationale for treating allergic and nonallergic rhinitis

Asthma Phenotypes Defined From Parameters Obtained During Recovery From a Hospital-Treated Exacerbation Rihuang Qiu, MD, Jiaxing Xie, MD, PhD, Kian Fan.

High-titer IgE antibody specific for pollen allergens in northern California is associated with both wheezing and total serum IgE Elizabeth A. Erwin,

Fatty acids, inflammation, and asthma

Chlamydophila (Chlamydia) pneumoniae serology and asthma in adults: A longitudinal analysis Rafael Pasternack, MD, PhD, Heini Huhtala, MSc, Jussi Karjalainen,

Premature immune senescence during HIV-1 vertical infection relates with response to influenza vaccination Alberto Cagigi, PhD, Stefano Rinaldi, MSc,

Obstructive sleep apnea syndrome and inflammation

Santa Jeremy Ono, BA, PhD, Mark B. Abelson, MD

Atopic dermatitis: Age and race do matter!

Sputum indoleamine-2, 3-dioxygenase activity is increased in asthmatic airways by using inhaled corticosteroids Kittipong Maneechotesuwan, MD, PhD, Sirinya.

Is 9 more than 2 also in allergic airway inflammation?

Desensitization to Chemotherapeutic Agents

A role for phosphoinositol 3–kinase δ in the impairment of glucocorticoid responsiveness in patients with chronic obstructive pulmonary disease John.

Fatty acids, inflammation, and asthma

Lung T-cell responses to nontypeable Haemophilus influenzae in patients with chronic obstructive pulmonary disease Paul T. King, MD, PhD, Steven Lim,

Asthma therapy and airway remodeling

Volume 153, Issue 4, Pages (April 2018)

Lieuwe D. Bos, MSc, PhD, Peter J. Sterk, MD, PhD, Stephen J

Allergy testing in predicting outcome of open food challenge to peanut

Tobacco smoke as a risk factor for allergic sensitization in adults: Conclusions of a systematic review and meta-analysis Beatriz Mónico, MSc, Jorge.

The National Biome Initiative: An allergy perspective

Peter M. Wolfgram, MD, David B. Allen, MD

Asthma treatment and asthma prevention: A tale of 2 parallel pathways

Human asthma is characterized by more IRF5+ M1 and CD206+ M2 macrophages and less IL-10+ M2-like macrophages around airways compared with healthy airways

Jewlya Lynn, PhD, Sophie Oppenheimer, MS, MPH, Lorena Zimmer, MA

Reply Journal of Allergy and Clinical Immunology

Time for a paradigm shift in asthma treatment: From relieving bronchospasm to controlling systemic inflammation Leif Bjermer, MD Journal of Allergy.

News & Notes Journal of Allergy and Clinical Immunology

The role of the mast cell in the pathophysiology of asthma

Food allergy: A review and update on epidemiology, pathogenesis, diagnosis, prevention, and management Scott H. Sicherer, MD, Hugh A. Sampson, MD Journal.

Biosimilars and drug development in allergic and immunologic diseases

Daphne Koinis-Mitchell, PhD, Timothy Craig, DO, Cynthia A

Claus Bachert, MD, PhD, Cezmi A. Akdis, MD

Lisa G. Wood, PhD, Manohar L. Garg, PhD, Peter G. Gibson, MBBS

CC chemokine receptors CCR1 and CCR4 are expressed on airway mast cells in allergic asthma Kawa Amin, PhD, Christer Janson, MD, PhD, Ilkka Harvima, MD,

What is an “eosinophilic phenotype” of asthma?

Cephalosporin Side Chain Cross-reactivity

Increased sputum endotoxin levels are associated with an impaired lung function response to oral steroids in asthmatic patients Charles McSharry, PhD,

Granulomatous-lymphocytic Interstitial Lung Disease in a Patient with Common Variable Immunodeficiency Phil Lieberman, MD, John Routes, MD The Journal.

H. William Kelly, PharmD Journal of Allergy and Clinical Immunology

Autophagy: Nobel Prize 2016 and allergy and asthma research

Food allergy: Epidemiology, pathogenesis, diagnosis, and treatment

Advances in the approach to the patient with food allergy

E. Rand Sutherland, MD, MPH Journal of Allergy and Clinical Immunology

The impact of a history of asthma on long-term outcomes of people with newly diagnosed chronic obstructive pulmonary disease: A population study Tetyana.

Risk of oral food challenges

Benjamin Chaigne, MD, Hervé Watier, MD, PhD

Martin Brasholt, MD, Florent Baty, PhD, Hans Bisgaard, MD, DMSci

Measles and immunomodulation

Macrolide antibiotics and asthma treatment

Asthma: The past, future, environment, and costs

Interrupting IL-6–receptor signaling improves atopic dermatitis but associates with bacterial superinfection Alexander A. Navarini, MD, PhD, Lars E.

Environmental factors and eosinophilic esophagitis

Advances in pediatric asthma in 2007

News Beyond Our Pages Journal of Allergy and Clinical Immunology

Negative affect, medication adherence, and asthma control in children

Effect of codeine on objective measurement of cough in chronic obstructive pulmonary disease Jaclyn Smith, MD, PhD, Emily Owen, MPhil, John Earis, MD,

Natural history of cow’s milk allergy

Differences in airway remodeling between subjects with severe and moderate asthma Carmela Pepe, MD, Susan Foley, MD, Joanne Shannon, MD, Catherine Lemiere,

Primary prevention of asthma and allergy

The Editors' Choice Journal of Allergy and Clinical Immunology

Itching as a systemic disease

E. Rand Sutherland, MD, MPH, Barry J

Presentation transcript:

Nitrosative stress in the bronchial mucosa of severe chronic obstructive pulmonary disease Fabio L.M. Ricciardolo, MD, Gaetano Caramori, MD, PhD, Kazuhiro Ito, PhD, Armando Capelli, MD, Paola Brun, PhD, Giovanni Abatangelo, MD, Alberto Papi, MD, Kian Fan Chung, MD, Ian Adcock, PhD, Peter J. Barnes, MD, Claudio F. Donner, MD, Andrea Rossi, MD, Antonino Di Stefano, PhD Journal of Allergy and Clinical Immunology Volume 116, Issue 5, Pages 1028-1035 (November 2005) DOI: 10.1016/j.jaci.2005.06.034 Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 1 Photomicrographs showing the bronchial mucosa from a nonsmoker (A), a smoker with normal lung function (B), a patient with mild/moderate COPD (C), and a subject with severe COPD (D) immunostained for identification of NT+ cells (arrows) in the submucosa. Results are representative of those from 11 nonsmokers, 13 smokers with normal lung function, 14 patients with mild/moderate COPD, and 13 patients with severe COPD. E, Epithelium. Journal of Allergy and Clinical Immunology 2005 116, 1028-1035DOI: (10.1016/j.jaci.2005.06.034) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 2 Photomicrographs showing the bronchial mucosa from a nonsmoker (A), a smoker with normal lung function (B), a patient with mild/moderate COPD (C), and a subject with severe COPD (D) immunostained for identification of iNOS+ cells (arrows) in the submucosa. Results are representative of those from 11 nonsmokers, 13 smokers, 14 patients with mild/moderate COPD, and 13 patients with severe COPD. E, Epithelium. Journal of Allergy and Clinical Immunology 2005 116, 1028-1035DOI: (10.1016/j.jaci.2005.06.034) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 3 Photomicrographs showing the bronchial mucosa from a nonsmoker (A), a smoker with normal lung function (B), a patient with mild/moderate COPD (C), and a subject with severe COPD (D) immunostained for identification of eNOS+ cells (arrows) in the submucosa. Results are representative of those from 11 nonsmokers, 13 smokers with normal lung function, 14 patients with mild/moderate COPD, and 13 patients with severe COPD. E, Epithelium. Journal of Allergy and Clinical Immunology 2005 116, 1028-1035DOI: (10.1016/j.jaci.2005.06.034) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 4 Photomicrographs showing the bronchial mucosa from a nonsmoker (A), a smoker with normal lung function (B), a patient with mild/moderate COPD (C), and a subject with severe COPD (D) immunostained for identification of MPO+ cells (arrows) in the submucosa. Results are representative of those from 11 nonsmokers, 13 smokers with normal lung function, 14 patients with mild/moderate COPD, and 13 patients with severe COPD. E, Epithelium. Journal of Allergy and Clinical Immunology 2005 116, 1028-1035DOI: (10.1016/j.jaci.2005.06.034) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 5 Regression analysis between postbronchodilator FEV1 % predicted (A and C), FEV1/FVC % (B and D), and numbers of NT+ (A and B) and MPO+ (C and D) cells in the submucosa of all patients with COPD. Correlation coefficients were calculated by using the Spearman rank method. Journal of Allergy and Clinical Immunology 2005 116, 1028-1035DOI: (10.1016/j.jaci.2005.06.034) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions