Distinct Clinical Features of Infectious Complications in Adult T Cell Leukemia/Lymphoma Patients after Allogeneic Hematopoietic Stem Cell Transplantation:

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Distinct Clinical Features of Infectious Complications in Adult T Cell Leukemia/Lymphoma Patients after Allogeneic Hematopoietic Stem Cell Transplantation: A Retrospective Analysis in the Nagasaki Transplant Group Hidehiro Itonaga, Jun Taguchi, Takuya Fukushima, Hideki Tsushima, Shinya Sato, Koji Ando, Yasushi Sawayama, Emi Matsuo, Reishi Yamasaki, Yasuyuki Onimaru, Daisuke Imanishi, Yoshitaka Imaizumi, Shinichiro Yoshida, Tomoko Hata, Yukiyoshi Moriuchi, Sumihisa Honda, Yasushi Miyazaki Biology of Blood and Marrow Transplantation Volume 19, Issue 4, Pages 607-615 (April 2013) DOI: 10.1016/j.bbmt.2013.01.011 Copyright © 2013 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 1 Cumulative incidence of infection-related death after transplantation. The 95% confidence intervals at 1, 3, 5, and 10 years are shown in each infection-related mortality. (A) Infectious mortality was higher in the adult T cell leukemia/lymphoma (ATL) group than that in the 2 other groups. (B) In the ATL group, infectious mortalities were higher in patients with episodes of cytomegalovirus (CMV) infection than in those without, but the P value for this association was near the borderline of significance. Biology of Blood and Marrow Transplantation 2013 19, 607-615DOI: (10.1016/j.bbmt.2013.01.011) Copyright © 2013 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 2 Kaplan-Meier estimate of overall survival after transplantation. The 95% confidence intervals at 1, 3, 5, and 10 years are shown in each overall survival (OS). (A) OS of the adult T cell leukemia/lymphoma (ATL) group was significantly worse than that of either the acute myeloid leukemia (AML) or acute lymphoblastic leukemia/lymphoblastic lymphoma (ALL/LBL) group. (B) In ATL group, the OS of patients with episodes of cytomegalovirus (CMV) infection was significantly worse than those without. (C) In the ATL group, the OS of patients with episodes of bacterial infection was significantly worse than those without. Biology of Blood and Marrow Transplantation 2013 19, 607-615DOI: (10.1016/j.bbmt.2013.01.011) Copyright © 2013 American Society for Blood and Marrow Transplantation Terms and Conditions