Christine Detrembleur, PhD, Léon Plaghki, MD, PhD 

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Presentation transcript:

Quantitative assessment of intrathecally administered baclofen in spasticity  Christine Detrembleur, PhD, Léon Plaghki, MD, PhD  Archives of Physical Medicine and Rehabilitation  Volume 81, Issue 3, Pages 279-284 (March 2000) DOI: 10.1016/S0003-9993(00)90071-6 Copyright © 2000 American Congress of Rehabilitation Medicine and the American Academy of Physical Medicine and Rehabilitation Terms and Conditions

Fig. 1 Spasticity measurement system. Archives of Physical Medicine and Rehabilitation 2000 81, 279-284DOI: (10.1016/S0003-9993(00)90071-6) Copyright © 2000 American Congress of Rehabilitation Medicine and the American Academy of Physical Medicine and Rehabilitation Terms and Conditions

Fig. 2 Elastic (A) and viscous (B) stiffness (in N · m · rad−1) as a function of frequency of oscillation (in Hz). (●5, the median values for stiffness in the controls; ■, the median values for stiffness in patients before intrathecal administration of baclofen [session 1]; ♦, the median values for stiffness in patients 4 hours after intrathecal injection of a 50-μg bolus of baclofen [session 2]; ▴, the median values for stiffness in patients 36 hours after the intrathecal injection of baclofen [session 3]. The dashed lines indicate values calculated for the 25% and 75% quartiles. Archives of Physical Medicine and Rehabilitation 2000 81, 279-284DOI: (10.1016/S0003-9993(00)90071-6) Copyright © 2000 American Congress of Rehabilitation Medicine and the American Academy of Physical Medicine and Rehabilitation Terms and Conditions

Fig. 3 Phase diagram of viscous stiffness (in N · m · rad−1) versus elastic stiffness (in N · m · rad−1). The (●, the median values for stiffness in the controls; ■, median values for stiffness in patients before intrathecal administration of baclofen [session 1]; ♦, median values for stiffness in patients 4 hours after intrathecal injection of a 50-μg bolus of baclofen [session 2]; ▴, median values for stiffness in patients 36 hours after the intrathecal injection of baclofen [session 3]. The arrow represents the total stiffness vector at 12Hz in the controls. Archives of Physical Medicine and Rehabilitation 2000 81, 279-284DOI: (10.1016/S0003-9993(00)90071-6) Copyright © 2000 American Congress of Rehabilitation Medicine and the American Academy of Physical Medicine and Rehabilitation Terms and Conditions

Fig. 4 Typical records from a control subject (35-year-old male; records A to C) and from a patient (patient 2) before (records D to F) and 4 hours after a 50-μg intrathecal bolus injection of baclofen (records G to I). Each record consists of 3 traces showing, from top to bottom: surface EMG of the triceps surae, torque response at the ankle, and 5° sinusoidal displacement of the ankle joint (±2.5° around neutral position). The upward displacement is the direction of dorsal flexion of the ankle (F and upward arrow). The 3 rows represent, from top to bottom, records obtained at different frequencies of oscillation: respectively, 4Hz (records A, D, and G), 7Hz (records B, E, and H), and 9Hz (records C, F, and I). Archives of Physical Medicine and Rehabilitation 2000 81, 279-284DOI: (10.1016/S0003-9993(00)90071-6) Copyright © 2000 American Congress of Rehabilitation Medicine and the American Academy of Physical Medicine and Rehabilitation Terms and Conditions