Diagnostic Applicability of In Vivo Confocal Laser Scanning Microscopy in Melanocytic Skin Tumors Armin Gerger, Silvia Koller, Thomas Kern, Cesare Massone,

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Date of download: 9/17/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Morphologic Features of Melanophages Under In Vivo.

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Diagnostic Applicability of In Vivo Confocal Laser Scanning Microscopy in Melanocytic Skin Tumors Armin Gerger, Silvia Koller, Thomas Kern, Cesare Massone, Karin Steiger, Erika Richtig, Helmut Kerl, Josef Smolle Journal of Investigative Dermatology Volume 124, Issue 3, Pages 493-498 (March 2005) DOI: 10.1111/j.0022-202X.2004.23569.x Copyright © 2005 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 1 Melanocyte cytology. Confocal images show round to oval and bright tumor cells in benign nevi (A) and large and polymorphic cells in melanoma (B). Journal of Investigative Dermatology 2005 124, 493-498DOI: (10.1111/j.0022-202X.2004.23569.x) Copyright © 2005 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 2 Architecture. Nevus cell nests are clearly seen in benign common nevi (A) but less defined in dysplastic nevi (B). Melanoma tends to show disarray of architecture (C). Journal of Investigative Dermatology 2005 124, 493-498DOI: (10.1111/j.0022-202X.2004.23569.x) Copyright © 2005 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 3 Keratinocyte cell borders (nuclei appear as dark ovals surrounded by bright and grainy cytoplasm). Readily detected (arrows) and focal loss (asterisk) in benign nevi (A), poorly defined or absent in melanoma (B). Journal of Investigative Dermatology 2005 124, 493-498DOI: (10.1111/j.0022-202X.2004.23569.x) Copyright © 2005 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 4 Dendrite-like structures. When present, frequently seen in melanoma with a complex branching pattern. Note, however, the regularly distributed keratinocytes surrounding the tumor cell nest of this melanoma in situ image. Journal of Investigative Dermatology 2005 124, 493-498DOI: (10.1111/j.0022-202X.2004.23569.x) Copyright © 2005 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 5 Reliability (interobserver agreement (A)) and reproducibility (intraobserver agreement (B)) of morphologic features. For evaluating the reproducibility, the morphologic features were assessed twice at an intervall of 3 mo by two observers. Journal of Investigative Dermatology 2005 124, 493-498DOI: (10.1111/j.0022-202X.2004.23569.x) Copyright © 2005 The Society for Investigative Dermatology, Inc Terms and Conditions