Hemodynamics and aneurysm development in vascular allografts

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Presentation transcript:

Hemodynamics and aneurysm development in vascular allografts Michael J. Petersen, MD, William M. Abbott, MD, Peter B. H'Doubler, MD, Gilbert J. L'Italien, BS, Bernice E. Hoppel, MS, Bruce R. Rosen, MD, PhD, John T. Fallon, MD, PhD, Roslyn W. Orkin, PhD Journal of Vascular Surgery Volume 18, Issue 6, Pages 955-964 (December 1993) DOI: 10.1016/0741-5214(93)90550-6 Copyright © 1993 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 1 Macroscopic in vivo photographs. (Original magnification × 10.) A, Aneurysmal SHR host aortic allograft 18 weeks after transplant. B, WKY host aortic allograft, as in A. One grid square = 1 mm. Journal of Vascular Surgery 1993 18, 955-964DOI: (10.1016/0741-5214(93)90550-6) Copyright © 1993 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 2 Photomicrographs of SHR host (A) and WKY host (B) aortic allografts. (Hematoxyling and eosin stain. Original magnification X40). Vascular lumen at bottom of photograph. Note mononuclear adventitial infiltrate, lack of smooth muscle cell nuclei, and intimal proliferation. Journal of Vascular Surgery 1993 18, 955-964DOI: (10.1016/0741-5214(93)90550-6) Copyright © 1993 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 3 Percent increase of transverse diameter of aortic graft at harvest. Auto, Autograft; Allo, allograft; Sens WKY, skin graft-sensitized WKY host; Sens SHR, skin graft-sensitized SHR host. Journal of Vascular Surgery 1993 18, 955-964DOI: (10.1016/0741-5214(93)90550-6) Copyright © 1993 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 4 A, Antihypertensive treatment of SHR: treated versus untreated SHR's systolic blood pressure. Open circles represent treated SHR host, open triangles represent untreated SHR host, and filled symbols represent directly measured arterial pressure. B, Treated versus untreated SHR's mean transverse aortic diameter as measured by MRI. Symbols as in A; filled symbols represent visually measured aortic diameters at harvest. Journal of Vascular Surgery 1993 18, 955-964DOI: (10.1016/0741-5214(93)90550-6) Copyright © 1993 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 5 MRI of SHR aortic allograft. Aorta (large arrow) and vena cava (small arrow) are visable anterior to paraspinal musculature. Journal of Vascular Surgery 1993 18, 955-964DOI: (10.1016/0741-5214(93)90550-6) Copyright © 1993 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 6 Maximum dp/dt as measured directly in treated and untreated SHR hosts and age-matched WKY rats. Journal of Vascular Surgery 1993 18, 955-964DOI: (10.1016/0741-5214(93)90550-6) Copyright © 1993 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions