Topical imiquimod treatment of a cutaneous melanomametastasis

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Presentation transcript:

Topical imiquimod treatment of a cutaneous melanomametastasis Alexander Steinmann, MD a, Jens Oliver Funk, MD, Gerold Schuler, MD, Peter von den Driesch, MD Journal of the American Academy of Dermatology Volume 43, Issue 3, Pages 555-556 (September 2000) DOI: 10.1067/mjd.2000.10795 Copyright © 2000 American Academy of Dermatology, Inc Terms and Conditions

Fig. 1 A, Melanoma metastases, left breast, before treatment (March 30, 1999). B, Residual hyperpigmentation and hypopigmentation and scars from biopsies, left breast, after treatment (Sept 7, 1999). Journal of the American Academy of Dermatology 2000 43, 555-556DOI: (10.1067/mjd.2000.10795) Copyright © 2000 American Academy of Dermatology, Inc Terms and Conditions

Fig. 2 Photomicrographs of biopsy specimens after imiquimod treatment. A, Small tumor cell islands are surrounded by dense lymphocytic infiltrates. B, Dense lymphocytic infiltrates surround necrotic tumor cells, extensive presence of melanophages. Journal of the American Academy of Dermatology 2000 43, 555-556DOI: (10.1067/mjd.2000.10795) Copyright © 2000 American Academy of Dermatology, Inc Terms and Conditions

Fig. 3 Photomicrographs of biopsy specimens after imiquimod treatment. A, Complete regression of tumor cells; only melanophages intermingled with lymphocytic infiltrates are present. B, Demonstration of CD8 expression on lymphocytes intermingling with melanophages. Journal of the American Academy of Dermatology 2000 43, 555-556DOI: (10.1067/mjd.2000.10795) Copyright © 2000 American Academy of Dermatology, Inc Terms and Conditions