PLase cleavage sites in phosphatidylcholine and cellular activities of the reaction products. PLase cleavage sites in phosphatidylcholine and cellular.

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PLase cleavage sites in phosphatidylcholine and cellular activities of the reaction products. PLase cleavage sites in phosphatidylcholine and cellular activities of the reaction products. PLA1s remove the fatty acid at the sn-1 position of the glycerol moiety, while PLA2s remove it at the sn-2 position, generating cellular mediators like lysophosphatidylcholine and arachidonic acid. PLBs hydrolyze both acyl groups from the glycerophospholipid and also exhibit LPLA activity. PLCs hydrolyze the glycerol-oriented phosphodiester bond, releasing DAG and a phosphorylated head group [e.g., IP3, acting on PI(4,5)P2, or choline phosphate acting on PC]. PLDs cleave the alcohol-oriented phosphodiester bond, releasing the head group (e.g., choline or inositol) and generating LPA. (Based on data from reference 82.)‏ Marietta Flores-Díaz et al. Microbiol. Mol. Biol. Rev. 2016; doi:10.1128/MMBR.00082-15