Schematic illustration summarizing the effect of orthopedic mice surgery on hippocampal astrocyte-neuron metabolism, structure, and function. Schematic.

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Schematic illustration summarizing the effect of orthopedic mice surgery on hippocampal astrocyte-neuron metabolism, structure, and function. Schematic illustration summarizing the effect of orthopedic mice surgery on hippocampal astrocyte-neuron metabolism, structure, and function. Orthopedic surgery in mice (i.e., tibia fracture) temporally orchestrates a series of hippocampal metabolic, structural, and functional changes first in the astrocyte and later in neurons that emphasize the role of astrocytes as key intermediaries between peripheral immune events and neuronal processing information and potentially to cognition. Red arrows depict decreased mRNA/protein levels. Teresa Femenía et al. J. Neurosci. 2018;38:452-464 ©2018 by Society for Neuroscience