Frederikke K. Lomholt, BMSc, Sune F. Nielsen, PhD, Børge G

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Presentation transcript:

High alcohol consumption causes high IgE levels but not high risk of allergic disease Frederikke K. Lomholt, BMSc, Sune F. Nielsen, PhD, Børge G. Nordestgaard, MD, DMSc Journal of Allergy and Clinical Immunology Volume 138, Issue 5, Pages 1404-1413.e13 (November 2016) DOI: 10.1016/j.jaci.2016.05.022 Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Comparison of the study design from observational studies, Mendelian randomization studies, and randomized controlled trials as applied to high and low alcohol consumption on IgE levels and risk of allergic disease. Journal of Allergy and Clinical Immunology 2016 138, 1404-1413.e13DOI: (10.1016/j.jaci.2016.05.022) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Number of subjects entering the different analyses. Journal of Allergy and Clinical Immunology 2016 138, 1404-1413.e13DOI: (10.1016/j.jaci.2016.05.022) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Associations between allergic disease and IgE levels examined in 38,802 subjects from the Copenhagen General Population Study. The top graph shows the association between allergic disease score and IgE levels, and the bottom graph shows the association between individual allergic diseases and IgE levels. Left, Multivariable adjusted odds ratios. Right, Geometric means. OR, Odds ratio. Journal of Allergy and Clinical Immunology 2016 138, 1404-1413.e13DOI: (10.1016/j.jaci.2016.05.022) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 4 Association between self-reported alcohol consumption and allergic disease and IgE levels examined in 47,336 subjects from the Copenhagen General Population Study and Copenhagen City Heart Study combined. The association was studied both overall and stratified for allergic disease status. Left, Multivariable adjusted odds ratios. Right, Crude geometric mean. OR, Odds ratio. Journal of Allergy and Clinical Immunology 2016 138, 1404-1413.e13DOI: (10.1016/j.jaci.2016.05.022) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 5 Association between self-reported alcohol consumption and allergic disease examined in 102,843 subjects from the Copenhagen General Population Study and Copenhagen City Heart Study combined. OR, Odds ratio. Journal of Allergy and Clinical Immunology 2016 138, 1404-1413.e13DOI: (10.1016/j.jaci.2016.05.022) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 6 Associations between ADH-genotype combinations and IgE levels examined in 44,848 subjects from the Copenhagen General Population Study and Copenhagen City Heart Study combined. OR, Odds ratio. Journal of Allergy and Clinical Immunology 2016 138, 1404-1413.e13DOI: (10.1016/j.jaci.2016.05.022) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 7 Observational and genetic estimates for increases in IgE levels with an increase in alcohol consumption of 1 drink per week. In total, 102,270 subjects with information on genotype from the Copenhagen General Population Study and Copenhagen City Heart Study were included in the analyses. OR, Odds ratio. Journal of Allergy and Clinical Immunology 2016 138, 1404-1413.e13DOI: (10.1016/j.jaci.2016.05.022) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Odds ratios for having 1 allergic disease compared with no allergic disease at different cutoff values for IgE levels. The red line shows the chosen cutoff value of 150 kU/L. Journal of Allergy and Clinical Immunology 2016 138, 1404-1413.e13DOI: (10.1016/j.jaci.2016.05.022) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E2 Association between self-reported alcohol consumption and allergic disease examined in 102,843 subjects from the Copenhagen General Population Study and Copenhagen City Heart Study combined. The analysis was stratified for sex. OR, Odds ratio. Journal of Allergy and Clinical Immunology 2016 138, 1404-1413.e13DOI: (10.1016/j.jaci.2016.05.022) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E3 Association between self-reported alcohol consumption and allergic disease examined in 102,834 subjects from the Copenhagen General Population Study and Copenhagen City Heart Study combined. The analysis was stratified for age less than or greater than the median age of 58 years. OR, Odds ratio. Journal of Allergy and Clinical Immunology 2016 138, 1404-1413.e13DOI: (10.1016/j.jaci.2016.05.022) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E4 Association between self-reported alcohol consumption and allergic disease examined in 102,611 subjects from the Copenhagen General Population Study and Copenhagen City Heart Study combined. The analysis was stratified for ever versus never smoking. OR, Odds ratio. Journal of Allergy and Clinical Immunology 2016 138, 1404-1413.e13DOI: (10.1016/j.jaci.2016.05.022) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E5 Associations between ADH-genotype combinations and risk of allergic disease examined in 98,457 subjects from the Copenhagen General Population Study and Copenhagen City Heart Study combined. OR, odds ratio. Journal of Allergy and Clinical Immunology 2016 138, 1404-1413.e13DOI: (10.1016/j.jaci.2016.05.022) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions