Advanced glycation end products contribute to the immunogenicity of IFN-β pharmaceuticals Angelina Bozhinov, PhD, Yordan Handzhiyski, PhD, Krasimir Genov,

Slides:

Advertisements

Similar presentations

Control of immunopathology during chikungunya virus infection Caroline Petitdemange, PhD, Nadia Wauquier, PhD, Vincent Vieillard, PhD Journal of Allergy.

Advertisements

Differentiation stage determines pathologic and protective allergen-specific CD4+ T-cell outcomes during specific immunotherapy Erik Wambre, PhD, Jonathan.

D-dimer: A biomarker for antihistamine-resistant chronic urticaria

The human polysaccharide- and protein-specific immune response to Streptococcus pneumoniae is dependent on CD4+ T lymphocytes, CD14+ monocytes, and the.

Birch pollen–related food allergy: Clinical aspects and the role of allergen-specific IgE and IgG4 antibodies Marija Geroldinger-Simic, MD, Thomas Zelniker,

High-titer IgE antibody specific for pollen allergens in northern California is associated with both wheezing and total serum IgE Elizabeth A. Erwin,

Effects of time, albuterol, and budesonide on the shape of the flow-volume loop in children with asthma Anand C. Patel, MD, Mark L. Van Natta, MHS, James.

Kyoung-Bok Min, MD, PhD, Jin-Young Min, PhD

Exploring the repertoire of IgE-binding self-antigens associated with atopic eczema Sabine Zeller, MSc, Claudio Rhyner, PhD, Norbert Meyer, MD, Peter.

Santa Jeremy Ono, BA, PhD, Mark B. Abelson, MD

Ann-Marie M. Schoos, MD, PhD, Jacob D

Giant ragweed specific immunotherapy is not effective in a proportion of patients sensitized to short ragweed: Analysis of the allergenic differences.

Stephen J. Fowler, MD, Gaël Tavernier, PhD, Robert Niven, MD

Dorothy M. Ryan, MD, Stephen J. Fowler, MD, Robert M. Niven, MD

Diagnosing IgE-mediated hypersensitivity to sesame by an immediate-reading “contact test” with sesame oil Cristiana Alonzi, MD, Paolo Campi, MD, Francesco.

Is 9 more than 2 also in allergic airway inflammation?

Correction Journal of Allergy and Clinical Immunology

In vivo allergenic activity of a hypoallergenic mutant of the major fish allergen Cyp c 1 evaluated by means of skin testing Nikolaos Douladiris, MD,

Component-resolved diagnosis of baker's allergy based on specific IgE to recombinant wheat flour proteins∗ Ingrid Sander, PhD, Hans-Peter Rihs, PhD,

Leticia Vila, MD, PhD, Borja Bartolome, PhD, Ana Moreno, MD

Lieuwe D. Bos, MSc, PhD, Peter J. Sterk, MD, PhD, Stephen J

Anaphylactic reaction to (mixed) fruit juice containing dragon fruit

Affinity purification of latex antigens

Asthma symptom re-emergence after omalizumab withdrawal correlates well with increasing IgE and decreasing pharmacokinetic concentrations Raymond G.

William J. Calhoun, MD, Tmirah Haselkorn, PhD, Dave P

Allison K. Martin, BS, Douglas G. Mack, PhD, Michael T

Mechanisms underlying differential food allergy response to heated egg

Protein unfolding strongly modulates the allergenicity and immunogenicity of Pru p 3, the major peach allergen Masako Toda, PhD, Gerald Reese, PhD, Gabriele.

Jon Genuneit, MD, MSc Journal of Allergy and Clinical Immunology

Phillip Lieberman, MD, Michael Tankersley, MD

Time for a paradigm shift in asthma treatment: From relieving bronchospasm to controlling systemic inflammation Leif Bjermer, MD Journal of Allergy.

Serum free light chains in the differential diagnosis and prognosis of primary and secondary hypogammaglobulinemia Nicolò Compagno, MD, Francesco Cinetto,

Food allergy: A review and update on epidemiology, pathogenesis, diagnosis, prevention, and management Scott H. Sicherer, MD, Hugh A. Sampson, MD Journal.

Biosimilars and drug development in allergic and immunologic diseases

IκB kinase–driven nuclear factor-κB activation in patients with asthma and chronic obstructive pulmonary disease Rosalia Gagliardo, PhD, Pascal Chanez,

Karen C. Dannemiller, PhD, Janneane F. Gent, PhD, Brian P

Grass tablet sublingual immunotherapy downregulates the TH2 cytokine response followed by regulatory T-cell generation Abel Suárez-Fueyo, PhD, Tania.

Differentiation stage determines pathologic and protective allergen-specific CD4+ T-cell outcomes during specific immunotherapy Erik Wambre, PhD, Jonathan.

What is an “eosinophilic phenotype” of asthma?

Allergy to cooked white potatoes in infants and young children: A cause of severe, chronic allergic disease Liliane F.A. De Swert, MD, Pascal Cadot,

Cephalosporin Side Chain Cross-reactivity

Molecular cloning and expression in insect cells of honeybee venom allergen acid phosphatase (Api m 3) Thomas Grunwald, PhD, Benjamin Bockisch, PhD,

Autophagy: Nobel Prize 2016 and allergy and asthma research

Food allergy: Epidemiology, pathogenesis, diagnosis, and treatment

Advances in the approach to the patient with food allergy

Accuracy of US Food and Drug Administration–cleared IgE antibody assays in the presence of anti-IgE (omalizumab) Robert G. Hamilton, PhD, DABMLI Journal.

Geographic variability in childhood asthma prevalence in Chicago

Association between specific timothy grass antigens and changes in TH1- and TH2-cell responses following specific immunotherapy Véronique Schulten, PhD,

A hypoallergenic cat vaccine based on Fel d 1–derived peptides fused to hepatitis B PreS Katarzyna Niespodziana, MSc, Margarete Focke-Tejkl, PhD, Birgit.

The human polysaccharide- and protein-specific immune response to Streptococcus pneumoniae is dependent on CD4+ T lymphocytes, CD14+ monocytes, and the.

Paul V. Licciardi, PhD, Anne Balloch, MSc, Fiona M

Birch pollen–related food allergy: Clinical aspects and the role of allergen-specific IgE and IgG4 antibodies Marija Geroldinger-Simic, MD, Thomas Zelniker,

Cat IgA, representative of new carbohydrate cross-reactive allergens

Benjamin Chaigne, MD, Hervé Watier, MD, PhD

Martin Brasholt, MD, Florent Baty, PhD, Hans Bisgaard, MD, DMSci

Allergy to human seminal fluid: Cross-reactivity with dog dander

Pedro Gamboa, MD, PhD, Rosa Sanchez-Monge, PhD, M

Profilin (Che a 2) and polcalcin (Che a 3) are relevant allergens of Chenopodium album pollen: Isolation, amino acid sequences, and immunologic properties

Päivi M. Salo, PhD, Samuel J. Arbes, DDS, MPH, PhD, Patrick W

Teresa Asensio, MD, Jesus F

Identification of wheat gliadins as an allergen family related to baker's asthma Cordula Bittner, MD, Britta Grassau, MS, Karsten Frenzel, PhD, Xaver.

Asthma: The past, future, environment, and costs

Interrupting IL-6–receptor signaling improves atopic dermatitis but associates with bacterial superinfection Alexander A. Navarini, MD, PhD, Lars E.

Placental transfer of allergen-specific IgG but not IgE from a specific immunotherapy– treated mother Sabine Flicker, PhD, Katharina Marth, MD, Heinz.

Environmental factors and eosinophilic esophagitis

Efficacy of a short course of specific immunotherapy in patients with allergic rhinoconjunctivitis to ragweed pollen Piyush Patel, MD, Tom Holdich, MBBS,

Advances in pediatric asthma in 2007

Natural history of cow’s milk allergy

Perturbations of natural killer cell regulatory functions in respiratory allergic diseases Francesca Scordamaglia, MD, Mirna Balsamo, PhD, Antonio Scordamaglia,

Increased immune reactivity to central nervous system–derived naturally presented peptides in patients with active multiple sclerosis Christine Riedhammer,

Presentation transcript:

Advanced glycation end products contribute to the immunogenicity of IFN-β pharmaceuticals Angelina Bozhinov, PhD, Yordan Handzhiyski, PhD, Krasimir Genov, MD, PhD, Vera Daskalovska, MD, DSc, Toshimitsu Niwa, MD, PhD, Ivan Ivanov, DSc, Roumyana Mironova, PhD Journal of Allergy and Clinical Immunology Volume 129, Issue 3, Pages 855-858.e6 (March 2012) DOI: 10.1016/j.jaci.2011.10.035 Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 IFN-β1a and IFN-β1b have undergone structural alterations. A, SE-HPLC chromatogram of Betaferon. B, Native PAGE (lane 1) and SDS-PAGE (lane 2) of Betaferon. C, Immunoblot of Betaferon SE-HPLC fraction no. 1 with an anti–IFN-β antibody. D, Silver-stained SDS polyacrylamide gel of Rebif. In Fig 1, C and D, degradation and covalent aggregation are indicated by solid arrows, and M stands for molecular mass standards in kilodaltons. Journal of Allergy and Clinical Immunology 2012 129, 855-858.e6DOI: (10.1016/j.jaci.2011.10.035) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Titers of anti–IFN-β (A, C, and E) and anti-AGE (B, D, and F) antibodies. Data are means ± SDs (n = 2) and are representative of 3 independent experiments. Sera from patients with multiple sclerosis with average titers greater than the mean + 3 SDs of the control group (dashed line) were considered positive (black and gray bars). G, Inhibition of the reactivity of sera R6 (solid circles) and B7 (solid triangles) to IFN-β by AGE-BSA. H, Anti–IFN-β antibody–positive sera in which the reactivity to IFN-β was significantly (P < .05) inhibited by AGE-BSA. In Fig 2, G and H, inhibition is presented as the percentage difference in sera reactivity to IFN-β in the presence of either AGE-free (100%) or AGE-modified BSA. Data are means from 8 replicates, and the difference was tested for statistical significance by using the paired 2-tailed Student t test. ∗P < .05, ∗∗P < .001, and ∗∗∗P < .0001. Journal of Allergy and Clinical Immunology 2012 129, 855-858.e6DOI: (10.1016/j.jaci.2011.10.035) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Correlation of the levels of anti–IFN-β antibodies with the levels of anti-AGE antibodies in the sera of patients with multiple sclerosis treated with Avonex (A), Rebif (B), and Betaferon (C). Correlation coefficients were calculated with the CORREL function of Microsoft Office Excel 2003 (Microsoft, Redmond, Wash), and their statistical significance was evaluated (http://faculty.vassar.edu/lowry/rsig.html). Journal of Allergy and Clinical Immunology 2012 129, 855-858.e6DOI: (10.1016/j.jaci.2011.10.035) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions