Fig. 2. Correlation between Aβ42 and Aβ40 levels in iNPH, AD, and CN subjects. The scatter plot shows the correlation between Aβ42 and Aβ40 levels. Representative.

Slides:



Advertisements
Similar presentations
Research Follow the evidence…. How to look at the brain Brain structure –CT –MRI Brain activity –PET –fMRI.
Advertisements

Figure 1.1 The observer in the truck sees the ball move in a vertical path when thrown upward. (b) The Earth observer views the path of the ball as a parabola.
There are currently 26 million people worldwide with Alzheimer’s disease. This figure is projected to grow to more than 106 million people by 2050.
Risk of Developing Alzheimer’s Disease in Persons with MCI
Normal Brain Images: Brain cross sections: Horizontal through the top of the skull: medlib.med.utah.edu/WebPath/HISTHTML/ANATOMY/VHM1080R.html.
Diagnostic Imaging Tests  MRI  CT  Ultrasound  PET scan  Mammography  X-ray.
NIDA’s mission is to bring the power of science to bear on drug abuse and addiction.
HOW CAN NEUROIMAGING HELP UNDERSTAND, DIAGNOSE, AND DEVELOP TREATMENTS FOR ALZHEIMER'S DISEASE? Part C – AD brain scans - anatomical NUCLEAR MEDICINE GRAND.
Explain how biological factors may affect one cognitive process.
NEUROBIOLOGY ACTIVITY 2&3 POSITRON EMISSION TOMOGRAPHY (PET) IMAGES.
Date of download: 6/3/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Mechanism of Amyloid Removal in Patients With Alzheimer.
Positron Emission Tomography.
SYNTHESIS Particles & Force-Fields 1.What is force? 2.Detecting particles 3.“Empty” space.
Biology and Behavior Neuroscience  Scientific study of the brain and of the links between brain activity and behavior.
Chicken Pox in the United States x y # of years after 1988 Chicken Pox in the U.S.A. YearCases (Thousands)
Date of download: 7/8/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Association of Plasma Clusterin Concentration With.
Fig. 2. Arterial fluorodeoxyglucose (FDG) uptake related to atherosclerosis. On positron emission tomography (PET) coronal (A), PET/CT fusion coronal (B),
Fig F-fluoride positron emission tomography (PET) in atherosclerosis
Correlation of 18F-FDG Avid Volumes on Pre–Radiation Therapy and Post–Radiation Therapy FDG PET Scans in Recurrent Lung Cancer  Nadya Shusharina, PhD,
Volume 3, Issue 1, Pages (January 2017)
Cognitive Effects of Subthalamic Nucleus Stimulation in Parkinson’s Disease: A Controlled Study Eur Neurol 2012;68:361–366 - DOI: / Fig.
Correlations between amyloid and metabolic pet imaging in cognitively normal adults with a family history of late-onset Alzheimer's disease  Megan Cummings,
Copyright © 2004 American Medical Association. All rights reserved.
(A) Scatter plot correlating the infant mortality rate and the K index
Lisa A. Weissfeld Professor and Associate Chair Dept. of Biostatistics
Neurobiology Activity 2&3
Fig. 11. Algorithm for differential diagnosis of cognitive impaired subjects by employing structural imaging. AD = Alzheimer's disease, BG = basal ganglia,
Fig. 2. Comparison of ROC curves for the FR and TR of both versions of the FCSRT for discriminating mild AD patients from cognitively healthy controls.
A multinational study distinguishing Alzheimer's and healthy patients using cerebrospinal fluid tau/Aβ42 cutoff with concordance to amyloid positron emission.
Alzheimer's & Dementia: The Journal of the Alzheimer's Association
Image Challenge Q: A 70-year-old woman presented to the neurology clinic with a 2-year history of gait disturbance, cognitive impairment, and urinary incontinence.
Recommendations for cerebrospinal fluid Alzheimer's disease biomarkers in the diagnostic evaluation of mild cognitive impairment  Sanna-Kaisa Herukka,
Alzheimer's & Dementia: The Journal of the Alzheimer's Association
Positron emission tomography (PET scan)
Algorithms proposed by the Heart Valve Clinic International Database (HAVEC) group for disease staging and management in patients with aortic valve stenosis.
Imaging AD Progression Amyloid Imaging Agents.
Amyloid Imaging for Alzheimer's Disease in Practice
Nat. Rev. Neurol. doi: /nrneurol
Reisa Sperling, Elizabeth Mormino, Keith Johnson  Neuron 
Notes Over 2.5 Positive Correlation Determining Correlation x
Paraneoplastic Opsoclonus-Myoclonus Syndrome as a New and Single Manifestation of Relapsing Disease in a Patient with Small Cell Lung Cancer  Ernest Nadal,
A B 1 (5,2), (8, 8) (3,4), (2, 1) 2 (-2,1), (1, -11) (-2,3), (-3, 2) 3
Towards a neural basis of auditory sentence processing
Meta-Analysis of Positron Emission Tomographic and Computed Tomographic Imaging in Detecting Mediastinal Lymph Node Metastases in Nonsmall Cell Lung Cancer 
C. P. Bleeker-Rovers, A. Warris, J. P. H. Drenth, F. H. M. Corstens, W
Figure 1 Tau PET images in patients with Alzheimer disease
Tharick A. Pascoal, Sulantha Mathotaarachchi, Monica Shin, Andrea L
Toward defining the preclinical stages of Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups.
Salvage Operation in Case of Oligometastatic Disease
Clifford R. Jack, Heather J. Wiste, Stephen D. Weigand, Terry M
Figure 1 Flortaucipir PET MUBADA/PERSI SUVr at baseline, 9 and 18 months for individual subjects. Each subject is ... Figure 1 Flortaucipir PET MUBADA/PERSI.
Molecular Interactions of Alzheimer's Biomarker FDDNP with Aβ Peptide
[18F]flutemetamol amyloid positron emission tomography in preclinical and symptomatic Alzheimer's disease: Specific detection of advanced phases of amyloid-β.
Longitudinal uncoupling of cerebral perfusion, glucose metabolism, and tau deposition in Alzheimer's disease  Antoine Leuzy, Elena Rodriguez-Vieitez,
Florbetaben PET imaging to detect amyloid beta plaques in Alzheimer's disease: Phase 3 study  Osama Sabri, Marwan N. Sabbagh, John Seibyl, Henryk Barthel,
Comparison of visual and quantitative florbetapir-PET reads in subjects with early Alzheimer's disease for assessing amyloid burden  Bradley Wyman, Yahong.
Positron emission tomography (PET) images of a fasted and fed (1 day postfeeding) Burmese python. Positron emission tomography (PET) images of a fasted.
Fig. 1. AD biomarker levels in the cerebrospinal fluid of iNPH, AD, and CN subjects. Box plots of Aβ42 (A), Aβ40 (B), Aβ42/Aβ40 ratio (C), t-tau (D),
CT (left of images) showing calcified areas and PET (right of images) scans showing increased FDG-PET metabolic activity in the mediastinal mass (A) and.
Fig. 1. A: Ictal EEG during a nonhabitual seizure
Detecting and Diagnosing Alzheimer’s Disease
Correlation of changes in NAFCIST and PERCIST with cumulative activity with radium RaCl2 dose was negatively correlated with changes in NAFCIST.
Figure 2 Aβ-PET scans obtained using different tracers
CSF biomarkers of Alzheimer's disease concord with amyloid-β PET and predict clinical progression: A study of fully automated immunoassays in BioFINDER.
Fig. 1. Pedigree of the patient's family and brain MR images of the cousin of the patient and MR and Pittsburgh compound-B (PiB) positron emission tomography.
18F-dopa positron emission tomography (PET) in a normal subject, a patient with idiopathic Parkinson's disease (PD), and a patient with multiple system.
Fig. 2. SUVmax on PET-CT and associated characteristics
Scatter plot of serum OPN levels and its correlation with patient survival. Scatter plot of serum OPN levels and its correlation with patient survival.
18F-NaF positron emission tomography–computed tomography (PET-CT) in abdominal aortic aneurysm disease. 18F-NaF positron emission tomography–computed tomography.
Box plot showing the distribution of the TYM-MCI score for patients with SMC and aMCI/AD. aMCI/AD, amnestic mild cognitive impairment or Alzheimer’s disease;
Presentation transcript:

Fig. 2. Correlation between Aβ42 and Aβ40 levels in iNPH, AD, and CN subjects. The scatter plot shows the correlation between Aβ42 and Aβ40 levels. Representative images from an amyloid PET(+) AD scan and an amyloid PET(−) iNPH scan are shown on the right. Aβ: β-amyloid, AD: Alzheimer's disease, amyloid PET(+): amyloid positron-emission tomography-positive, amyloid PET(−): amyloid positron-emission tomography-negative, CN: cognitively normal, iNPH: idiopathic normal-pressure hydrocephalus. Fig. 2. Correlation between Aβ42 and Aβ40 levels in iNPH, AD, and CN subjects. The scatter plot shows the correlation between Aβ42 and Aβ40 levels. Representative images from an amyloid PET(+) AD scan and an amyloid PET(−) iNPH scan are shown on the right. Aβ: β-amyloid… J Clin Neurol. 2019 Jul;15(3):353-359. https://doi.org/10.3988/jcn.2019.15.3.353