Hypothermic responses to infection are inhibited by α2-adrenoceptor agonists with possible clinical implications S. Tolchard, P.A. Burns, D.J. Nutt, S.M. Fitzjohn British Journal of Anaesthesia Volume 103, Issue 4, Pages 554-560 (October 2009) DOI: 10.1093/bja/aep199 Copyright © 2009 British Journal of Anaesthesia Terms and Conditions
Fig 1 Time course of mean (sem) body temperature sampled at consecutive 5 min intervals for 30 min before and 120 min after a single i.v. injection (arrow) of either sterile saline (0.9%, 0.1 ml) or LPS (3.5 µg, 0.1 ml sterile saline) in rats receiving a continuous i.v. infusion (9 µl min−1) of either (a) sterile saline (0.9%), (b) mivazerol (4.8 µg−1 kg−1 h−1 in 0.9% sterile saline vehicle), (c) mivazerol (10 µg−1 kg−1 h−1 in 0.9% sterile saline vehicle), or (d) UK14304-18 (6 µg kg−1 h−1 in 0.9% sterile saline vehicle). For n values, see Table 1. British Journal of Anaesthesia 2009 103, 554-560DOI: (10.1093/bja/aep199) Copyright © 2009 British Journal of Anaesthesia Terms and Conditions
Fig 2 Time course of mean (sem) body temperature sampled at consecutive 5 min intervals for 30 min before and 120 min after a single i.v. injection (arrow) of either sterile saline (0.9%, 0.1 ml) or LPS (3.5 µg, 0.1 ml sterile saline) in rats receiving a continuous i.v. infusion of either (a) RX811059A (7 µg kg−1 h−1 in 0.9% sterile saline vehicle) or (b) mivazerol and RX811059A (4.8 and 7 µg kg−1 h−1, respectively, in 0.9% sterile saline vehicle). For n values, see Table 1. British Journal of Anaesthesia 2009 103, 554-560DOI: (10.1093/bja/aep199) Copyright © 2009 British Journal of Anaesthesia Terms and Conditions
Fig 3 Plasma corticosterone levels obtained after temperature measurement in animals receiving i.v. infusion/i.v. bolus injection. Data are plotted as median (circle) and range (error bars). For n values and drug concentrations, see Table 1. British Journal of Anaesthesia 2009 103, 554-560DOI: (10.1093/bja/aep199) Copyright © 2009 British Journal of Anaesthesia Terms and Conditions