Epidermal Interferon-γ Inducible Protein-10 (IP-10) and Monokine Induced by γ- Interferon (Mig) but not IL-8 mRNA Expression is Associated with Epidermotropism in Cutaneous T Cell Lymphomas  Cornelis P. Tensen, Maarten H. Vermeer, Petra M. van der Stoop, Peter van Beek, Rik J. Scheper, Dick M. Boorsma, Rein Willemze  Journal of Investigative Dermatology  Volume 111, Issue 2, Pages 222-226 (August 1998) DOI: 10.1046/j.1523-1747.1998.00263.x Copyright © 1998 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 1 Abundant epidermal IP-10 and Mig mRNA expression in early MF lesion.In situ hybridization with 35S-UTP-labeled IP-10 anti-sense RNA (a), Mig anti-sense (b), and IP-10 sense RNA probe (c) followed by emulsion autoradiography was performed on serial cryostat sections as described in Materials and Methods. (a, b) Large foci of silver grains representing sites of IP-10 and Mig mRNA transcripts in the epidermis. (c) Absence of silver grains in the epidermis with sense probe showing the specificity of the in situ hybridization procedure. Scale bar, 45 μm. Journal of Investigative Dermatology 1998 111, 222-226DOI: (10.1046/j.1523-1747.1998.00263.x) Copyright © 1998 The Society for Investigative Dermatology, Inc Terms and Conditions