Clinical characteristics and laboratory parameters in relation to dose of oral sodium bicarbonate. Clinical characteristics and laboratory parameters in relation to dose of oral sodium bicarbonate. Serum bicarbonate (A), serum potassium (B), systolic and diastolic BP (C), and body weight (D) in relation to dose of oral sodium bicarbonate. P values were calculated using mixed-effects models separately examining the association of sodium bicarbonate dose with repeated measurements of each outcome. Matthew K. Abramowitz et al. CJASN 2013;8:714-720 ©2013 by American Society of Nephrology