Fig. 10. COL15A1 is pervasive within advanced human atherosclerotic plaques and localized to the fibrous cap and intraplaque microvessels. A representative.

Slides:

Advertisements

Similar presentations

Normal Coronary Artery Images: Coronary artery: Microscopic image of a cross section of a coronary artery:

Advertisements

S. Shaikh, J. Brittenden, R. Lahiri, P. A. J. Brown, F. Thies, H. M

Transglutaminase activity regulates atherosclerotic plaque composition at locations exposed to oscillatory shear stress Hanke L. Matlung, Annette E.

Saskia Z. H. Rittersma, Martijn Meuwissen, Chris M

Volume 144, Issue 1, Pages 7-14 (May 1999)

Margreet de Vries1,2, Laura Parma1,2, Erna Peters1,2,

Results of Coronary Artery Endarterectomy and Coronary Artery Bypass Grafting for Diffuse Coronary Artery Disease Srikrishna Sirivella, MD, Isaac Gielchinsky,

Kindlin 3 (FERMT3) is associated with unstable atherosclerotic plaques, anti- inflammatory type II macrophages and upregulation of beta-2 integrins in.

Omega-6 polyunsaturated fatty acids prevent atherosclerosis development in LDLr-KO mice, in spite of displaying a pro-inflammatory profile similar to.

Heregulin, Cysteine Rich-61 and Matrix Metalloproteinase 9 Expression in Human Carotid Atherosclerotic Plaques: Relationship with Clinical Data F. Sigala,

Circ Cardiovasc Imaging

Pixel distribution analysis of B-mode ultrasound scan images predicts histologic features of atherosclerotic carotid plaques Brajesh K. Lal, MDa, Robert.

Jie-Hong Pan, MD, PhD. a, Jes S. Lindholt, MD, PhD. b, Galina K

Leena Khaitan, MD, Francis P Sutter, Scott M Goldman, MD

High-flow gas insufflation to facilitate MIDCABG: effects on coronary endothelium William R Burfeind, MD, Francis G Duhaylongsod, MD, Brian H Annex, MD,

Christopher K. Zarins, MD, Chengpei Xu, MD, Seymour Glagov, MD

Histologic characterization of mobile and nonmobile carotid plaques detected with ultrasound imaging Takeshi Funaki, MD, Koji Iihara, MD, PhD, Susumu.

Acute inflammation with induction of anaphylatoxin C5a and terminal complement complex C5b-9 associated with multiple intra-articular injections of hylan.

Randolph L. Geary, MD, Seppo T. Nikkari, MD, William D. Wagner, PhD, J

Markers of instability in high-risk carotid plaques are reduced by statins Hagen Kunte, MD, Nicola Amberger, MD, Markus Alexander Busch, MD, MPH, Ralph-Ingo.

Coronary artery bypass grafting in patients with advanced left ventricular dysfunction Gregory D Trachiotis, MD, William S Weintraub, MD, Thomas S Johnston,

Atherosclerotic aneurysm formation in an in situ saphenous vein graft

Increased vascularization of shoulder regions of carotid atherosclerotic plaques from patients with diabetes Fredrik J. Olson, PhD, Sofia Strömberg,

Expression of heat shock protein–70 by dendritic cells in the arterial intima and its potential significance in atherogenesis Yuri V. Bobryshev, PhD,

International Journal of Cardiology

Chapter 12 Pathophysiology of Atherosclerosis

Value of Magnetic Resonance Imaging, Angiography, and Fractional Flow Reserve to Evaluate the Left Main Coronary Artery After Direct Surgical Angioplasty

Volume 383, Issue 9918, Pages (February 2014)

Pixel distribution analysis of B-mode ultrasound scan images predicts histologic features of atherosclerotic carotid plaques Brajesh K. Lal, MDa, Robert.

Impact of chronic kidney disease on carotid plaque vulnerability

Aneurysm formation in experimental atherosclerosis: Relationship to plaque evolution Christopher K. Zarins, MD, Seymour Glagov, MD, Dragoslava Vesselinovitch,

Fig. 4. Specific versus nonspecific NP accumulation.

Leptin receptor is elevated in carotid plaques from neurologically symptomatic patients and positively correlated with augmented macrophage density Jacob.

Histological evaluation disqualifies IMT and calcification scores as surrogates for grading coronary and aortic atherosclerosis Armelle Meershoek, Rogier.

Yukinori Moriyam, Riichiro Tod, Koichi Hisatom, Akira Tair

Endothelial injury and acquired aspirin resistance as promoters of regional thrombin formation and early vein graft failure after coronary artery bypass.

Heterozygosity for an inactivating mutation in low-density lipoprotein-related receptor 6 (Lrp6) increases osteoarthritis severity in mice after ligament.

Intravascular Ultrasound Analysis of the Radial Artery for Coronary Artery Bypass Grafting Akio Oshima, MD, Satoshi Takeshita, MD, Ken Kozuma, MD, Naoyuki.

Markers of instability in high-risk carotid plaques are reduced by statins Hagen Kunte, MD, Nicola Amberger, MD, Markus Alexander Busch, MD, MPH, Ralph-Ingo.

Iron and noncontrast magnetic resonance T2

Hisham S. Bassiouny, MD, Yashuhiro Sakaguchi, MD, Susanne A

Degree of carotid plaque calcification in relation to symptomatic outcome and plaque inflammation Wael E Shaalan, MD, Hongwei Cheng, MD, PhD, Bruce Gewertz,

Hermann Reichenspurner, MD, PhD, Jose A

Characterization of primary and restenotic atherosclerotic plaque from the superficial femoral artery: Potential role of Smad3 in regulation of SMC proliferation

Glenn C. Hunter, MD, Stephen H. Smyth, MD, Marie L. Aguirre, MD, B

Pathology of the Radial and Internal Thoracic Arteries Used as Coronary Artery Bypass Grafts Eric Kaufer, BS, Stephen M Factor, MD, Rosemary Frame, MS,

Intraoperative echocardiographic imaging of coronary arteries and graft anastomoses during coronary artery bypass grafting without cardiopulmonary bypass

Carotid plaque instability and ischemic symptoms are linked to immaturity of microvessels within plaques Benjamin J. Dunmore, PhD, Mark J. McCarthy,

Histopathological comparison between endofibrosis of the high-performance cyclist and atherosclerosis in the external iliac artery Aryan Vink, MD, PhD,

Reversal of refractory hypotension with single-dose methylene blue after coronary artery bypass surgery P. Yiu, FRCSa, J. Robin, MRCPb, C.W. Pattison,

Angiogenesis and the atherosclerotic carotid plaque: An association between symptomatology and plaque morphology Mark J. McCarthy, FRCS(Ed), Ian M. Loftus,

Matrix metalloproteinase 10 is associated with disease severity and mortality in patients with peripheral arterial disease Esther Martinez-Aguilar, MD,

Fig. 2. CD treatment facilitates regression of murine atherosclerosis.

Thomas E. Geyer, Madhava J. Naik, Ravi Pillai

Michael L. Marin, MD, Ronald E. Gordon, PhD, Frank J

Acute coronary syndromes: biology

Joseph J. Piotrowski, MD, Glenn C. Hunter, MD, Cleamond D

Randomized Controlled Trial of Pericardial Blood Processing With a Cell-Saving Device on Neurologic Markers in Elderly Patients Undergoing Coronary Artery.

Critical carotid stenoses: Morphologic and chemical similarity between symptomatic and asymptomatic plaques Hisham S. Bassiouny, MD, Harry Davis, PhD,

Fig. 6. Hepatocellular carcinoma showing irregular rim enhancement

Neointimal formation at the sites of anastomosis of the internal thoracic artery grafts after coronary artery bypass grafting in human subjects: An immunohistochemical.

Fig. 9. SMC-specific Col15a1 knockout resulted in downregulation of immune cell processes that impact atherosclerotic plaque formation. RNA-seq analysis.

Fig. 8. SMC Col15a1 knockout resulted in a decrease in lesion cell death. A: representative immunofluorescent images of SMC YFP+/+ Col15a1wt/wt, Apoe−/−

Fig. 5. Loss of SMC-specific COL15A1 resulted in overall reductions in the number of YFP+ SMC-derived cells within the lesions but an increase in YFP−galectin.

Angiotensin II induces histomorphologic features of unstable plaque in a murine model of accelerated atherosclerosis Valdeci da Cunha, PhD, Baby Martin-McNulty,

Targeted nanoparticles containing the proresolving peptide Ac2-26 protect against advanced atherosclerosis in hypercholesterolemic mice by Gabrielle Fredman,

Expression of PCNA, K10, and K5 in skin lesions from Stat3+/−:HPV8 and Stat3+/+:HPV8 mice. Expression of PCNA, K10, and K5 in skin lesions from Stat3+/−:HPV8.

Expression of CD40L and CD40 in human vascular atherosclerotic lesions in situ. Expression of CD40L and CD40 in human vascular atherosclerotic lesions.

Location of the Second Internal Mammary Artery Graft Does Not Influence Outcome of Coronary Artery Bypass Grafting Paul A. Kurlansky, MD, Ernest A. Traad,

Richard L. McCann, MD, R.Randal Bollinger, MD, Glenn E. Newman, MD

Presentation transcript:

Fig. 10. COL15A1 is pervasive within advanced human atherosclerotic plaques and localized to the fibrous cap and intraplaque microvessels. A representative image of a human coronary artery lesion from 1 of 6 patients analyzed who underwent coronary artery bypass surgery is shown. Serial sections were stained with COL15A1 (A) or traditional macrophage (CD68; B) and SMC marker (ACTA2) genes. C and D: boxes (1 and 2) represent regions of higher magnification to highlight COL15A1 presence in the ACTA2-rich fibrous cap (C and D) and intraplaque microvessels (D, blue arrows) with little to no COL15A1 staining in CD68-rich regions (D). DOI: (10.1152/ajpheart.00029.2017)