Vaccination of patients with mild and severe asthma with a 2009 pandemic H1N1 influenza virus vaccine William W. Busse, MD, Stephen P. Peters, MD, PhD,

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Presentation transcript:

Vaccination of patients with mild and severe asthma with a 2009 pandemic H1N1 influenza virus vaccine William W. Busse, MD, Stephen P. Peters, MD, PhD, Matthew J. Fenton, PhD, Herman Mitchell, PhD, Eugene R. Bleecker, MD, Mario Castro, MD, MPH, Sally Wenzel, MD, Serpil C. Erzurum, MD, Anne M. Fitzpatrick, PhD, W. Gerald Teague, MD, Nizar Jarjour, MD, Wendy C. Moore, MD, Kaharu Sumino, MD, PhD, Scott Simeone, MA, Suphagaphan Ratanamaneechat, MD, Madhuri Penugonda, MD, Benjamin Gaston, MD, Ted M. Ross, PhD, Steve Sigelman, RN, Joella R. Schiepan, MPH, MCRP, Daniel J. Zaccaro, MS, Corey J. Crevar, BS, MBA, Donald M. Carter, BS, MS, Alkis Togias, MD Journal of Allergy and Clinical Immunology Volume 127, Issue 1, Pages 130-137.e3 (January 2011) DOI: 10.1016/j.jaci.2010.11.014 Copyright © 2010 Terms and Conditions

Fig 1 Consolidated Standard of Reporting Trials diagram. Panels representing days 21, 28, and 41 report 2 groups of participants. First line, Participants who had their first vaccination on day 1 and blood draw on the indicated study visit. Second line, Participants who had their first vaccination on day 1, second vaccination on day 21, and blood draw on the indicated study visit. The group in the second line is a subgroup of the group in the first line. Randomization was stratified by investigative site, asthma severity group, and age group. Journal of Allergy and Clinical Immunology 2011 127, 130-137.e3DOI: (10.1016/j.jaci.2010.11.014) Copyright © 2010 Terms and Conditions

Fig 2 Geometric mean of 2009 pandemic H1N1 influenza virus serum HAI titers by asthma severity and vaccine dose groups. Horizontal lines represent the lower detection limit of the HAI assay (1:10), as well as the conventional seroprotection level (1:40). P values represent comparisons at days 21 and 41 between the 15- and 30-μg dose groups. A, Mild-to-moderate asthma. B, Severe asthma. Green lines represent 15 μg, and red lines represent 30 μg. Journal of Allergy and Clinical Immunology 2011 127, 130-137.e3DOI: (10.1016/j.jaci.2010.11.014) Copyright © 2010 Terms and Conditions

Fig 3 Age effect on seroprotection rates at day 21 by severity and dose-level group. A, Mild-to-moderate asthma. B, Severe asthma. Tables below each panel provide information on the number and percentage of participants per age group who were seroprotected. Journal of Allergy and Clinical Immunology 2011 127, 130-137.e3DOI: (10.1016/j.jaci.2010.11.014) Copyright © 2010 Terms and Conditions